The role of Optical Coherence Tomography (OCT) for the diagnosis, monitoring, and guiding of treatment for neovascular Age-related Macular Degeneration (nAMD): an evidence synthesis study

Noemi Lois, Augusto Azuara-Blanco, Graham Mowatt, Mayret Castillo de Chacon, Andrew Elders, Craig R Ramsay, Jennifer M Burr

Research output: Contribution to conferencePoster

Abstract

Purpose:To determine the optimal role of OCT in diagnosing and monitoring nAMD (detecting disease activity and the need for further anti-VEGF treatment).
Methods:Systematic review. Major electronic databases and websites were searched. Studies were included if they reported the diagnostic performance of time domain or spectral domain OCT (or selected other tests) against a reference standard of ophthalmologist-interpreted fluorescein angiography in people with newly suspected or previously diagnosed nAMD. Risk of bias was assessed by two independent investigators using QUADAS-2. Summary receiver operating characteristic (SROC) curves were produced for each test given sufficient data.
Results:3700 titles/abstracts were screened, and 120 (3.2%) were selected for full-text assessment. A total of 22 studies were included (17 on diagnosis, 7 monitoring, and 3 both). From 15 studies reporting OCT data, sensitivity and specificity ranged from 59% to 100% and 27% to 100%, respectively.
Conclusions:The reported diagnostic performance of OCT showed large variability. The methodological quality of most studies was sub-optimal.
Original languageEnglish
Publication statusPublished - 2013
EventARVO Annual Meeting (2013) - Seattle , United States
Duration: 05 May 201309 May 2013

Conference

ConferenceARVO Annual Meeting (2013)
CountryUnited States
CitySeattle
Period05/05/201309/05/2013

Bibliographical note

Invest Ophthalmol Vis Sci 2013;54: E-Abstract 6285.

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    Lois, N., Azuara-Blanco, A., Mowatt, G., Castillo de Chacon, M., Elders, A., Ramsay, C. R., & Burr, J. M. (2013). The role of Optical Coherence Tomography (OCT) for the diagnosis, monitoring, and guiding of treatment for neovascular Age-related Macular Degeneration (nAMD): an evidence synthesis study. Poster session presented at ARVO Annual Meeting (2013), Seattle , United States.