The role of secreted frizzled-related protein 2 expression in prostate cancer

Gillian O'Hurley, Antoinette S Perry, Anthony O'Grady, Barbara Loftus, Paul Smyth, John J O'Leary, Orla Sheils, John M Fitzpatrick, Stephen M Hewitt, Mark Lawler, Elaine W Kay, Mark Lawler

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


AIMS: Improved prostate cancer (PCa)-specific biomarkers are urgently required to distinguish between indolent and aggressive disease, in order to avoid overtreatment. In this study, we investigated the prostatic tissue expression of secreted frizzled-related protein (SFRP)-2.

METHODS AND RESULTS: Following immunohistochemical analysis on PCa tissue microarrays with samples from 216 patients, strong/moderate SFRP-2 expression was observed in epithelial cells of benign prostatic hyperplasia, and negative/weak SFRP-2 expression was observed in the majority of tumour epithelia. However, among Gleason grade 5 carcinomas, 40% showed strong/moderate SFRP-2 expression and 60% showed negative SFRP-2 expression in epithelial cells. Further microscopic evaluation of Gleason grade 5 tumours revealed different morphological patterns, corresponding with differential SFRP-2 expression. The first subgroup (referred to as Type A) appeared to have a morphologically solid growth pattern, whereas the second subgroup (referred to as Type B) appeared to have a more diffuse pattern. Furthermore, 100% (4/4) of Type A patients experienced biochemical recurrence, as compared with 0% (0/6) of Type B patients.

CONCLUSIONS: These results imply: (i) that there is a loss of SFRP-2 expression from benign to malignant prostate glands; and (ii) differential SFRP-2 expression among two possible subgroups of Gleason grade 5 tumours.

Original languageEnglish
Pages (from-to)1240-8
Number of pages9
Issue number6
Publication statusPublished - Dec 2011

Bibliographical note

© 2011 Blackwell Publishing Limited.


  • Adult
  • Aged
  • Carcinoma
  • Humans
  • Immunohistochemistry
  • Laser Capture Microdissection
  • Male
  • Membrane Proteins
  • Middle Aged
  • Precancerous Conditions
  • Prostatic Hyperplasia
  • Prostatic Neoplasms
  • Reverse Transcriptase Polymerase Chain Reaction
  • Tissue Array Analysis
  • Tumor Markers, Biological

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