The role of secretory leucoprotease inhibitor in the resolution of inflammatory responses

S Weldon, N McGarry, C C Taggart, N G McElvaney

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Chronic lung disease is one of the most common causes of death and disability worldwide. This group of diseases is characterized by a protease burden, an infective process and a dominant pro-inflammatory profile. While SLPI (secretory leucoprotease inhibitor) was initially identified as a serine protease inhibitor, it has since been shown that SLPI possesses other properties distinct from those associated with its antiprotease capabilities that play an important role in protecting the host from infection and injury. In the course of this review, we will highlight the findings from a range of studies that illustrate the multiple functions of SLPI and its role in the resolution of the immune response.
Original languageEnglish
Pages (from-to)273-6
JournalBiochemical society transactions
Volume35
Issue numberPt 2
DOIs
Publication statusPublished - Apr 2007

ASJC Scopus subject areas

  • Biochemistry

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