The Role of Therapeutic Layering in Optimizing Treatment for Patients with Castration-Resistant Prostate Cancer (RADAR II)

E David Crawford, Daniel P Petrylak, Neal Shore, Fred Saad, Susan F Slovin, Prof Nicholas J. Vogelzang, Thomas E Keane, Phillip J Koo, Leonard G Gomella, Joe M O'Sullivan, Bertrand Tombal, Raoul S Concepcion, Paul Sieber, Nelson N Stone, Steven E Finkelstein, Evan Y Yu, Prostate Cancer Radiographic Assessments for Detection of Advanced Recurrence (RADAR II) Group

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Abstract

Objective: To offer recommendations on identification of disease progression, treatment management strategies, and suggestions on timing of initiating and discontinuing specific CRPC treatments.

Materials and Methods: The RADAR II [Prostate Cancer Radiographic Assessments for Detection of Advanced Recurrence] Working Group convened to provide guidance on sequencing, combination, or layering of approved treatments for mCRPC based on available data and clinical experience.

Results: A consensus was developed to address important questions on mCRPC patient management.

Conclusions: In the absence of large scale clinical trials, the Working Group recommends that patients may best be managed with a layered approach of approved therapies with unique or complimentary mechanisms of action.
Original languageEnglish
JournalBMC Urology
Early online date14 Mar 2017
DOIs
Publication statusEarly online date - 14 Mar 2017

Keywords

  • Journal Article

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    Crawford, E. D., Petrylak, D. P., Shore, N., Saad, F., Slovin, S. F., Vogelzang, P. N. J., Keane, T. E., Koo, P. J., Gomella, L. G., O'Sullivan, J. M., Tombal, B., Concepcion, R. S., Sieber, P., Stone, N. N., Finkelstein, S. E., Yu, E. Y., & Prostate Cancer Radiographic Assessments for Detection of Advanced Recurrence (RADAR II) Group (2017). The Role of Therapeutic Layering in Optimizing Treatment for Patients with Castration-Resistant Prostate Cancer (RADAR II). BMC Urology. https://doi.org/10.1016/j.urology.2016.12.033