The role of Y chromosome deletions in male infertility.

K. Ma, Con Mallidis, S. Bhasin

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Male infertility affects approximately 2-7% of couples around the world. Over one in ten men who seek help at infertility clinics are diagnosed as severely oligospermic or azoospermic. Recent extensive molecular studies have revealed that deletions in the azoospermia factor region of the long arm of the Y chromosome are associated with severe spermatogenic impairment (absent or severely reduced germ cell development). Genetic research into male infertility, in the last 7 years, has resulted in the isolation of a great number of genes or gene families on the Y chromosome, some of which are believed to influence spermatogenesis.
Original languageEnglish
Pages (from-to)418-430
Number of pages13
JournalEuropean journal of endocrinology / European Federation of Endocrine Societies
Volume142(5)
Issue number5
Publication statusPublished - May 2000

ASJC Scopus subject areas

  • Endocrinology

Fingerprint Dive into the research topics of 'The role of Y chromosome deletions in male infertility.'. Together they form a unique fingerprint.

  • Cite this