The roles of Pellino E3 ubiquitin ligases in immunity

Paul N Moynagh

doi:10.1038/nri3599

The roles of Pellino E3 ubiquitin ligases in immunity

Paul N Moynagh

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article

57 Citations (Scopus)

Abstract

Pellino proteins were initially characterized as a family of E3 ubiquitin ligases that can catalyse the ubiquitylation of interleukin-1 receptor-associated kinase 1 (IRAK1) and regulate innate immune signalling pathways. More recently, physiological and molecular roles for members of the Pellino family have been described in the regulation of innate and adaptive immune responses by ubiquitylation. This Review describes the emerging roles of Pellino proteins in innate and adaptive immunity and discusses the mechanistic basis of these functions.

Original language	English
Pages (from-to)	122-31
Number of pages	10
Journal	Nature reviews. Immunology
Volume	14
Issue number	2
Early online date	21 Jan 2014
DOIs	https://doi.org/10.1038/nri3599
Publication status	Published - Feb 2014

Keywords

Animals
Humans
Immunity, Innate
Nod2 Signaling Adaptor Protein
Nuclear Proteins
Protein Processing, Post-Translational
Signal Transduction
Toll-Like Receptors
Ubiquitin-Protein Ligases

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Moynagh, P. N. (2014). The roles of Pellino E3 ubiquitin ligases in immunity. Nature reviews. Immunology, 14(2), 122-31. https://doi.org/10.1038/nri3599

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