The roles of TRIO and F-actin-binding protein in glioblastoma cells

Hyunji Lee, Minhee Kim, Jisoo Park, Quangdon Tran, Youngeun Hong, Hyeonjeong Cho, Sungjin Park, Suntaek Hong, Derek P. Brazil, Seon Hwan Kim, Jongsun Park*

*Corresponding author for this work

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Abstract

TRIO and F-actin-binding protein (TrioBP), which was initially discovered as a binding partner of Trio and F-actin, is a critical factor associated with hearing loss in humans. However, the function of TrioBP in cancer has not been investigated. In the present study, TrioBP expression was indicated to be highly elevated in U87-MG and U343-MG cells. Furthermore, the TrioBP mRNA expression level was markedly increased in U87-MG and U251-MG cells compared with that in cerebral cortex cells, as determined by deep sequencing. Comprehensive analysis of a public TCGA dataset confirmed that TrioBP expression is elevated in patients with glioblastoma. In summary, the present data indicate that TrioBP expression is increased in glioblastoma cell lines and in patients with glioma, suggesting that TrioBP has potential as a diagnostic marker or therapeutic agent for glioma.

Original languageEnglish
Pages (from-to)4540-4546
Number of pages7
JournalMolecular Medicine Reports
Volume17
Issue number3
Early online date18 Jan 2018
DOIs
Publication statusPublished - 01 Mar 2018

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Keywords

  • Biomarker
  • Cytoskeleton
  • Glioma
  • TrioBP

Cite this

Lee, H., Kim, M., Park, J., Tran, Q., Hong, Y., Cho, H., ... Park, J. (2018). The roles of TRIO and F-actin-binding protein in glioblastoma cells. Molecular Medicine Reports, 17(3), 4540-4546. https://doi.org/10.3892/mmr.2018.8458