The synapsin cycle: a view from the synaptic endocytic zone

E Evergren, F Benfenati, O Shupliakov

Research output: Contribution to journalArticlepeer-review

67 Citations (Scopus)

Abstract

Although the synapsin phosphoproteins were discovered more than 30 years ago and are known to play important roles in neurotransmitter release and synaptogenesis, a complete picture of their functions within the nerve terminal is lacking. It has been shown that these proteins play an important role in the clustering of synaptic vesicles (SVs) at active zones and function as modulators of synaptic strength by acting at both pre- and postdocking levels. Recent studies have demonstrated that synapsins migrate to the endocytic zone of central synapses during neurotransmitter release, which suggests that there are additional functions for these proteins in SV recycling.

Original languageEnglish
Pages (from-to)2648-56
Number of pages9
JournalJournal of neuroscience research
Volume85
Issue number12
DOIs
Publication statusPublished - Sep 2007

Bibliographical note

(c) 2007 Wiley-Liss, Inc.

Keywords

  • Animals
  • Axonal Transport
  • Models, Biological
  • Neurons
  • Neurotransmitter Agents
  • Synapses
  • Synapsins
  • Synaptic Vesicles

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