The synthesis and structure revision of NSC-134754

Jennie A. Hickin; Afshan Ahmed; Katharina Fucke; Margaret Ashcroft; Keith Jones

doi:10.1039/C3CC48189A

The synthesis and structure revision of NSC-134754

Jennie A. Hickin, Afshan Ahmed, Katharina Fucke, Margaret Ashcroft, Keith Jones

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

The synthesis of emetine analogue NSC-134754, a potent inhibitor of the HIF pathway, has been accomplished and its structure reassigned. The stereochemistry of NSC-134754 has been assigned for the first time using X-ray crystallography and it has been demonstrated that only one diastereoisomer is active against HIF. © 2014 The Royal Society of Chemistry.

Original language	English
Pages (from-to)	1238-1240
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	10
DOIs	https://doi.org/10.1039/C3CC48189A
Publication status	Published - 09 Dec 2013

Access to Document

10.1039/C3CC48189ALicence: Unspecified

Cite this

@article{3dc67be4d89b4adfacb0d75a41373d9a,

title = "The synthesis and structure revision of NSC-134754",

abstract = "The synthesis of emetine analogue NSC-134754, a potent inhibitor of the HIF pathway, has been accomplished and its structure reassigned. The stereochemistry of NSC-134754 has been assigned for the first time using X-ray crystallography and it has been demonstrated that only one diastereoisomer is active against HIF. {\textcopyright} 2014 The Royal Society of Chemistry.",

author = "Hickin, {Jennie A.} and Afshan Ahmed and Katharina Fucke and Margaret Ashcroft and Keith Jones",

year = "2013",

month = dec,

day = "9",

doi = "10.1039/C3CC48189A",

language = "English",

volume = "50",

pages = "1238--1240",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "10",

}

TY - JOUR

T1 - The synthesis and structure revision of NSC-134754

AU - Hickin, Jennie A.

AU - Ahmed, Afshan

AU - Fucke, Katharina

AU - Ashcroft, Margaret

AU - Jones, Keith

PY - 2013/12/9

Y1 - 2013/12/9

N2 - The synthesis of emetine analogue NSC-134754, a potent inhibitor of the HIF pathway, has been accomplished and its structure reassigned. The stereochemistry of NSC-134754 has been assigned for the first time using X-ray crystallography and it has been demonstrated that only one diastereoisomer is active against HIF. © 2014 The Royal Society of Chemistry.

AB - The synthesis of emetine analogue NSC-134754, a potent inhibitor of the HIF pathway, has been accomplished and its structure reassigned. The stereochemistry of NSC-134754 has been assigned for the first time using X-ray crystallography and it has been demonstrated that only one diastereoisomer is active against HIF. © 2014 The Royal Society of Chemistry.

U2 - 10.1039/C3CC48189A

DO - 10.1039/C3CC48189A

M3 - Article

C2 - 24336320

SN - 1359-7345

VL - 50

SP - 1238

EP - 1240

JO - Chemical Communications

JF - Chemical Communications

IS - 10

ER -

The synthesis and structure revision of NSC-134754

Abstract

Access to Document

Fingerprint

Cite this