The synthesis and structure revision of NSC-134754

Jennie A. Hickin, Afshan Ahmed, Katharina Fucke, Margaret Ashcroft, Keith Jones

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13 Citations (Scopus)

Abstract

The synthesis of emetine analogue NSC-134754, a potent inhibitor of the HIF pathway, has been accomplished and its structure reassigned. The stereochemistry of NSC-134754 has been assigned for the first time using X-ray crystallography and it has been demonstrated that only one diastereoisomer is active against HIF. © 2014 The Royal Society of Chemistry.
Original languageEnglish
Pages (from-to)1238-1240
Number of pages3
JournalChemical Communications
Volume50
Issue number10
DOIs
Publication statusPublished - 09 Dec 2013

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    Hickin, J. A., Ahmed, A., Fucke, K., Ashcroft, M., & Jones, K. (2013). The synthesis and structure revision of NSC-134754. Chemical Communications, 50(10), 1238-1240. https://doi.org/10.1039/C3CC48189A