The synthesis and structure revision of NSC-134754

Jennie A. Hickin; Afshan Ahmed; Katharina Fucke; Margaret Ashcroft; Keith Jones

doi:10.1039/C3CC48189A

The synthesis and structure revision of NSC-134754

Jennie A. Hickin
, Afshan Ahmed
, Katharina Fucke
, Margaret Ashcroft
, Keith Jones

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

The synthesis of emetine analogue NSC-134754, a potent inhibitor of the HIF pathway, has been accomplished and its structure reassigned. The stereochemistry of NSC-134754 has been assigned for the first time using X-ray crystallography and it has been demonstrated that only one diastereoisomer is active against HIF. © 2014 The Royal Society of Chemistry.

Original language	English
Pages (from-to)	1238-1240
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	10
DOIs	https://doi.org/10.1039/C3CC48189A
Publication status	Published - 09 Dec 2013

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title = "The synthesis and structure revision of NSC-134754",

abstract = "The synthesis of emetine analogue NSC-134754, a potent inhibitor of the HIF pathway, has been accomplished and its structure reassigned. The stereochemistry of NSC-134754 has been assigned for the first time using X-ray crystallography and it has been demonstrated that only one diastereoisomer is active against HIF. {\textcopyright} 2014 The Royal Society of Chemistry.",

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AU - Hickin, Jennie A.

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AU - Fucke, Katharina

AU - Ashcroft, Margaret

AU - Jones, Keith

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AB - The synthesis of emetine analogue NSC-134754, a potent inhibitor of the HIF pathway, has been accomplished and its structure reassigned. The stereochemistry of NSC-134754 has been assigned for the first time using X-ray crystallography and it has been demonstrated that only one diastereoisomer is active against HIF. © 2014 The Royal Society of Chemistry.

U2 - 10.1039/C3CC48189A

DO - 10.1039/C3CC48189A

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JO - Chemical Communications

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The synthesis and structure revision of NSC-134754

Abstract

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