The type II secretion system - a dynamic fiber assembly nanomachine

Manuel Campos, David A. Cisneros, Mangayarkarasi Nivaskumar, Olivera Francetic

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48 Citations (Scopus)

Abstract

Type II secretion systems (T2SSs) share common origins and structure with archaeal flagella (archaella) and pili, bacterial competence systems and type IV pili. All of these systems use a conserved ATP-powered machinery to assemble helical fibers that are anchored in the plasma membrane. The T2SSs assemble pseudopili, periplasmic filaments that promote extracellular secretion of folded periplasmic proteins. Comparative analysis of T2SSs and related fiber assembly nanomachines might provide important clues on their functional specificities and dynamics. This review focuses on recent developments in the study of pseudopilus structure and biogenesis, and discusses mechanistic models of pseudopilus function in protein secretion.
Original languageEnglish
Pages (from-to)545-555
Number of pages11
JournalResearch in Microbiology
Volume164
Issue number6
Early online date27 Mar 2013
DOIs
Publication statusPublished - Aug 2013

Bibliographical note

<p>Campos, Manuel<br/>Cisneros, David A<br/>Nivaskumar, Mangayarkarasi<br/>Francetic, Olivera<br/>eng<br/>Research Support, Non-U.S. Gov't<br/>Review<br/>France<br/>2013/04/02<br/>Res Microbiol. 2013 Jul-Aug;164(6):545-55. doi: 10.1016/j.resmic.2013.03.013. Epub 2013 Mar 27.</p>

The following values have no corresponding Zotero field:<br/>auth-address: Institut Pasteur, Molecular Genetics Unit, Department of Microbiology, 75015 Paris, France.<br/>edition: 20130327<br/>accession-num: 23542426<br/>remote-database-provider: NLM

Keywords

  • Protein Transport
  • Type IV pili
  • Fimbriae, Bacterial/genetics/*metabolism
  • *Bacterial Secretion Systems
  • Bacteria/genetics/*metabolism
  • Bacterial Proteins/genetics/*metabolism
  • Cell Membrane/genetics/*metabolism
  • Pilus assembly
  • Pseudopilins
  • Type II protein secretion

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