The Ubiquitin Proteasome System in Genome Stability and Cancer

Jonathan J. Morgan, Lisa J. Crawford*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)
135 Downloads (Pure)


Faithful DNA replication during cellular division is essential to maintain genome stability and cells have developed a sophisticated network of regulatory systems to ensure its integrity. Disruption of these control mechanisms can lead to loss of genomic stability, a key hallmark of cancer. Ubiquitination is one of the most abundant regulatory post-translational modifications and plays a pivotal role in controlling replication progression, repair of DNA and genome stability. Dysregulation of the ubiquitin proteasome system (UPS) can contribute to the initiation and progression of neoplastic transformation. In this review we provide an overview of the UPS and summarize its involvement in replication and replicative stress, along with DNA damage repair. Finally, we discuss how the UPS presents as an emerging source for novel therapeutic interventions aimed at targeting genomic instability, which could be utilized in the treatment and management of cancer.
Original languageEnglish
Pages (from-to)e2235
Issue number9
Early online date06 May 2021
Publication statusEarly online date - 06 May 2021


  • ubiquitination
  • genome stability
  • DNA replication
  • DNA damage
  • cancer


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