Therapeutic targets for the treatment of chronic cough

N. A. Roe; F. T. Lundy; G. J.  Litherland; L. P. A. McGarvey

doi:10.1007/s40136-019-00239-9

Therapeutic targets for the treatment of chronic cough

N. A. Roe, F. T. Lundy, G. J. Litherland, L. P. A. McGarvey^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

219 Downloads (Pure)

Abstract

Purpose of Review
Chronic cough, defined in adults as one lasting longer than 8 weeks, is among the commonest clinical problems encountered by doctors both in general practice and in hospital. It can exist as a distinct clinical problem or as a prominent and troublesome symptom for patients with common pulmonary conditions including asthma, chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis.

Recent Findings
Chronic cough impacts considerably on patients’ daily-life activities and many patients are left frustrated by what they see as a complete lack of awareness among their doctors as how to treat their condition. Some of this arises from limited levels of physician knowledge about managing cough as a clinical problem but also because there are no very effective treatments that specifically target cough.

Summary
In this article, we review the current clinical thinking regarding cough and the treatments that are currently used and those undergoing clinical development.

Original language	English
Pages (from-to)	116-128
Journal	Current Otorhinolaryngology Reports
Volume	7
DOIs	https://doi.org/10.1007/s40136-019-00239-9
Publication status	Published - 02 May 2019

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10.1007/s40136-019-00239-9Licence: CC BY

Therapeutic targets for the treatment of chronic cough
Copyright 2019 The Authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 471 KBLicence: CC BY

Vice-Chancellor's Research Culture Prize 2020
Martin, L. (Recipient), Lundy, F. (Recipient) & McGarvey, L. (Recipient), 17 Dec 2020
Prize: Prize (including medals and awards)

QUEEN'S SECURES EU FUNDING FOR FIGHT AGAINST LUNG DISEASE
Martin, L., McGarvey, L. & Lundy, F.
26/01/2017
1 Media contribution
Press/Media: Research

Neuroinflammatory consequences of rhinovirus infection in the human airway
Roe, N. (Author), McGarvey, L. (Supervisor), Lundy, F. (Supervisor) & Martin, L. (Supervisor), Jul 2022
Student thesis: Doctoral Thesis › Doctor of Philosophy

Cite this

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title = "Therapeutic targets for the treatment of chronic cough",

abstract = "Purpose of ReviewChronic cough, defined in adults as one lasting longer than 8 weeks, is among the commonest clinical problems encountered by doctors both in general practice and in hospital. It can exist as a distinct clinical problem or as a prominent and troublesome symptom for patients with common pulmonary conditions including asthma, chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis.Recent FindingsChronic cough impacts considerably on patients{\textquoteright} daily-life activities and many patients are left frustrated by what they see as a complete lack of awareness among their doctors as how to treat their condition. Some of this arises from limited levels of physician knowledge about managing cough as a clinical problem but also because there are no very effective treatments that specifically target cough.SummaryIn this article, we review the current clinical thinking regarding cough and the treatments that are currently used and those undergoing clinical development.",

author = "Roe, {N. A.} and Lundy, {F. T.} and Litherland, {G. J.} and McGarvey, {L. P. A.}",

year = "2019",

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doi = "10.1007/s40136-019-00239-9",

language = "English",

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journal = "Current Otorhinolaryngology Reports",

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AU - Roe, N. A.

AU - Lundy, F. T.

AU - Litherland, G. J.

AU - McGarvey, L. P. A.

PY - 2019/5/2

Y1 - 2019/5/2

N2 - Purpose of ReviewChronic cough, defined in adults as one lasting longer than 8 weeks, is among the commonest clinical problems encountered by doctors both in general practice and in hospital. It can exist as a distinct clinical problem or as a prominent and troublesome symptom for patients with common pulmonary conditions including asthma, chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis.Recent FindingsChronic cough impacts considerably on patients’ daily-life activities and many patients are left frustrated by what they see as a complete lack of awareness among their doctors as how to treat their condition. Some of this arises from limited levels of physician knowledge about managing cough as a clinical problem but also because there are no very effective treatments that specifically target cough.SummaryIn this article, we review the current clinical thinking regarding cough and the treatments that are currently used and those undergoing clinical development.

AB - Purpose of ReviewChronic cough, defined in adults as one lasting longer than 8 weeks, is among the commonest clinical problems encountered by doctors both in general practice and in hospital. It can exist as a distinct clinical problem or as a prominent and troublesome symptom for patients with common pulmonary conditions including asthma, chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis.Recent FindingsChronic cough impacts considerably on patients’ daily-life activities and many patients are left frustrated by what they see as a complete lack of awareness among their doctors as how to treat their condition. Some of this arises from limited levels of physician knowledge about managing cough as a clinical problem but also because there are no very effective treatments that specifically target cough.SummaryIn this article, we review the current clinical thinking regarding cough and the treatments that are currently used and those undergoing clinical development.

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DO - 10.1007/s40136-019-00239-9

M3 - Article

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VL - 7

SP - 116

EP - 128

JO - Current Otorhinolaryngology Reports

JF - Current Otorhinolaryngology Reports

ER -

Therapeutic targets for the treatment of chronic cough

Abstract

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Prizes

Vice-Chancellor's Research Culture Prize 2020

Press/Media

QUEEN'S SECURES EU FUNDING FOR FIGHT AGAINST LUNG DISEASE

Student theses

Neuroinflammatory consequences of rhinovirus infection in the human airway

Cite this