Three component coupling reactions of N-acetyl-2-azetine-rapid stereoselective entry to 2,3,4-trisubstituted tetrahydroquinolines

Paul Stevenson; Mark Nieuwenhuyzen; D. Osborne

doi:10.1039/b110242g

Three component coupling reactions of N-acetyl-2-azetine-rapid stereoselective entry to 2,3,4-trisubstituted tetrahydroquinolines

Paul Stevenson, Mark Nieuwenhuyzen, D. Osborne

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

N-Acetyl-2-azetine undergoes Lewis acid catalysed [4 + 2]-cycloaddition with imines derived from aromatic amines and gave a 1:1 mixture of exo-endo diastereoisomeric azetidine cycloadducts which reacted further with aromatic amine, to give 2,3,4-trisubsitituted tetrahydroquinolines in good to excellent yield, predominantly as one diastereoisomer.

Original language	English
Pages (from-to)	444-445
Number of pages	2
Journal	Chemical Communications
Volume	5
Issue number	5
DOIs	https://doi.org/10.1039/b110242g
Publication status	Published - 07 Mar 2002

ASJC Scopus subject areas

General Chemistry

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Three component coupling reactions of N-acetyl-2-azetine-rapid stereoselective entry to 2,3,4-trisubstituted tetrahydroquinolines

Abstract

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