Three component coupling reactions of N-acetyl-2-azetine-rapid stereoselective entry to 2,3,4-trisubstituted tetrahydroquinolines

Paul Stevenson, Mark Nieuwenhuyzen, D. Osborne

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

N-Acetyl-2-azetine undergoes Lewis acid catalysed [4 + 2]-cycloaddition with imines derived from aromatic amines and gave a 1:1 mixture of exo-endo diastereoisomeric azetidine cycloadducts which reacted further with aromatic amine, to give 2,3,4-trisubsitituted tetrahydroquinolines in good to excellent yield, predominantly as one diastereoisomer.
Original languageEnglish
Pages (from-to)444-445
Number of pages2
JournalChemical Communications
Volume5
Issue number5
DOIs
Publication statusPublished - 07 Mar 2002

ASJC Scopus subject areas

  • Chemistry(all)

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