Thrombin-induced conversion of fibrinogen to fibrin results in rapid platelet trapping which is not dependent on platelet activation or GPIb

Gavin Jarvis, B.T. Atkinson, J. Frampton, S.P. Watson

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

1 Activation of human platelets by thrombin is mediated by the proteolytic cleavage of two G-protein coupled protease-activated receptors, PAR-1 and PAR-4. However, thrombin also binds specifically to the platelet surface glycoprotein GPIb. It has been claimed that thrombin can induce aggregation of platelets via a novel GPIb-mediated pathway, which is independent of PAR activation and fibrinogen binding to alpha(IIb)beta(3) integrin, but dependent upon polymerizing fibrin and the generation of intracellular signals.
Original languageEnglish
Pages (from-to)574-583
Number of pages10
JournalBritish Journal of Pharmacology
Volume138
Issue number4
DOIs
Publication statusPublished - Feb 2003

ASJC Scopus subject areas

  • Pharmacology

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