Abstract
Tigecycline resistance in Klebsiella pneumoniae results from ramA upregulation that causes the overexpression of the efflux pump, AcrAB-TolC. Tigecycline mutants, derived from Ecl8?ramA, can exhibit a multidrug resistance phenotype due to increased transcription of the marA, rarA, acrAB, and oqxAB genes. These findings support the idea that tigecycline or multidrug resistance in K. pneumoniae, first, is not solely dependent on the ramA gene, and second, can arise via alternative regulatory pathways in K. pneumoniae. © 2012, American Society for Microbiology.
| Original language | English |
|---|---|
| Pages (from-to) | 4466-4467 |
| Number of pages | 2 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 56 |
| Issue number | 8 |
| Early online date | 29 May 2012 |
| DOIs | |
| Publication status | Published - Aug 2012 |
ASJC Scopus subject areas
- Pharmacology (medical)
- Pharmacology
- Infectious Diseases
Access to Document
- Tigecycline Resistance Can Occur Independently of the ramA Gene in Klebsiella pneumoniae
Copyright © 2012, American Society for Microbiology. All Rights Reserved. The authors have paid a fee to allow immediate free access to this article.