Tigecycline Resistance Can Occur Independently of the ramA Gene in Klebsiella pneumoniae

Mark Veleba, Thamarai Schneiders

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)
173 Downloads (Pure)


Tigecycline resistance in Klebsiella pneumoniae results from ramA upregulation that causes the overexpression of the efflux pump, AcrAB-TolC. Tigecycline mutants, derived from Ecl8?ramA, can exhibit a multidrug resistance phenotype due to increased transcription of the marA, rarA, acrAB, and oqxAB genes. These findings support the idea that tigecycline or multidrug resistance in K. pneumoniae, first, is not solely dependent on the ramA gene, and second, can arise via alternative regulatory pathways in K. pneumoniae. © 2012, American Society for Microbiology.
Original languageEnglish
Pages (from-to)4466-4467
Number of pages2
JournalAntimicrobial Agents and Chemotherapy
Issue number8
Early online date29 May 2012
Publication statusPublished - Aug 2012

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology
  • Infectious Diseases

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