Too large to fit? Recent developments in macromolecular imprinting

Yi Ge*, Anthony P F Turner

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

179 Citations (Scopus)


Molecular imprinting involves the synthesis of polymers in the presence of a template to produce complementary binding sites with specific recognition ability. The technique has been successfully applied as a measurement and separation technology, producing a uniquely robust and antibody-like polymeric material. Low molecular weight molecules have been extensively exploited as imprint templates, leading to significant achievements in solid-phase extraction, sensing and enzyme-like catalysis. By contrast, macromolecular imprinting remains underdeveloped, principally because of the lack of binding site accessibility. In this review, we focus on the most recent developments in this area, not only covering the widespread use of biological macro-templates but also highlighting the emerging use of synthetic macro-templates, such as dendrimers and hyperbranched polymers.

Original languageEnglish
Pages (from-to)218-224
Number of pages7
JournalTrends in Biotechnology
Issue number4
Publication statusPublished - Apr 2008
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering

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