“Top” or “Bottom” Switches of a Cyclohexanone Monooxygenase Controlling the Enantioselectivity of the Sandwiched Substrate

Yujing Hu, Jie Wang, Yixin Cen, He Zhang, Meilan Huang*, Qi Wu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)
119 Downloads (Pure)

Abstract

Single mutation at the switch residues F432 (F432I/L) or L435 (L435A/G) efficiently reversed the inherent enantiopreference of WT CHMOAcineto in the Baeyer–Villiger oxidation of various 4-phenyl-cyclohexanone derivatives and 4-alkyl-cyclohexanones, producing a series of substituted lactones with inversed configuration (up to 99% ee and 99% conversion).
Original languageEnglish
Pages (from-to)2198-2201
JournalChemical Communications
Volume55
Issue number15
Early online date25 Jan 2019
DOIs
Publication statusPublished - 21 Feb 2019

Bibliographical note

This is in interdisciplinary research in collaboration with Zhejiang Univ, China. It was conducted by a visiting PhD student from Zhejiang University.

Chemical Communications is a peer-reviewed journal with an Impact Factor of 6.2

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