“Top” or “Bottom” Switches of a Cyclohexanone Monooxygenase Controlling the Enantioselectivity of the Sandwiched Substrate

Yujing Hu; Jie Wang; Yixin Cen; He Zhang; Meilan Huang; Qi Wu

doi:10.1039/C8CC09951K

“Top” or “Bottom” Switches of a Cyclohexanone Monooxygenase Controlling the Enantioselectivity of the Sandwiched Substrate

Yujing Hu, Jie Wang, Yixin Cen, He Zhang, Meilan Huang^*, Qi Wu^*

^*Corresponding author for this work

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

223 Downloads (Pure)

Abstract

Single mutation at the switch residues F432 (F432I/L) or L435 (L435A/G) efficiently reversed the inherent enantiopreference of WT CHMOAcineto in the Baeyer–Villiger oxidation of various 4-phenyl-cyclohexanone derivatives and 4-alkyl-cyclohexanones, producing a series of substituted lactones with inversed configuration (up to 99% ee and 99% conversion).

Original language	English
Pages (from-to)	2198-2201
Journal	Chemical Communications
Volume	55
Issue number	15
Early online date	25 Jan 2019
DOIs	https://doi.org/10.1039/C8CC09951K
Publication status	Published - 21 Feb 2019

Bibliographical note

This is in interdisciplinary research in collaboration with Zhejiang Univ, China. It was conducted by a visiting PhD student from Zhejiang University.

Chemical Communications is a peer-reviewed journal with an Impact Factor of 6.2

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10.1039/C8CC09951KLicence: Unspecified

“Top” or “Bottom” Switches of a Cyclohexanone Monooxygenase Controlling the Enantioselectivity of the Sandwiched Substrate
© 2019 The Royal Society of Chemistry. This work is made available online in accordance with the publisher’s policies. Please refer to any applicable terms of use of the publisher.
Accepted author manuscript, 280 KBLicence: Unspecified

Meilan Huang
- m.huangqub.acuk
- School of Chemistry and Chemical Engineering - Senior Lecturer
- Theoretical and Applied Catalysis
Person: Academic

Cite this

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abstract = "Single mutation at the switch residues F432 (F432I/L) or L435 (L435A/G) efficiently reversed the inherent enantiopreference of WT CHMOAcineto in the Baeyer–Villiger oxidation of various 4-phenyl-cyclohexanone derivatives and 4-alkyl-cyclohexanones, producing a series of substituted lactones with inversed configuration (up to 99% ee and 99% conversion).",

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AU - Cen, Yixin

AU - Zhang, He

AU - Huang, Meilan

AU - Wu, Qi

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AB - Single mutation at the switch residues F432 (F432I/L) or L435 (L435A/G) efficiently reversed the inherent enantiopreference of WT CHMOAcineto in the Baeyer–Villiger oxidation of various 4-phenyl-cyclohexanone derivatives and 4-alkyl-cyclohexanones, producing a series of substituted lactones with inversed configuration (up to 99% ee and 99% conversion).

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DO - 10.1039/C8CC09951K

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“Top” or “Bottom” Switches of a Cyclohexanone Monooxygenase Controlling the Enantioselectivity of the Sandwiched Substrate

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Meilan Huang

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