Topical application of TAT-Superoxide Dismutase in Acupoints LI 20 on allergic rhinitis

Jing-Ke Guo, Ming-Ming Xu, Mei-Feng Zheng, Shu-Tao Liu, Jian-Wu Zhou, Li-Jing Ke, Tian-Bao Chen, Ping-Fan Rao

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Abstract

Reactive oxygen species are products of cellular metabolism and assigned important roles in biomedical science as deleterious factors in pathologies. In fact, some studies have shown that the therapeutic benefits of taking antioxidants were limited and the potential for therapeutic intervention remain unclear. New evidences showed that ROS have some ability of intercellular transportation. For treating allergic rhinitis, as a novel intracellular superoxide quencher, TAT-SOD applied to acupoints LI 20 instead of directly to nasal cavity can be used to test that. 56 subjects aged 18 to 43 years were recruited in this study. TTA group (n=21) apply 0.1 ml of 5000 U/ml TAT-SOD cream prepared by adding purified TAT-SOD to the vehicle cream in an area of 1cm2 to acupoints LI 20, while placebo group (n=17) used the vehicle cream instead. TTN group (n=18) applied 0.1 ml the same TAT-SOD cream directly to nasal cavity three times daily. Symptom scores were recorded at baseline, day 8 and 15. The overall therapeutic response evaluations were also carried out. Serum levels were determined of malondialdehyde, superoxide dismutase, catalase and glutathione peroxidase at baseline and day 15. For the overall efficacy rate, TTA group was 81.0% (17/21) while placebo group was 5.9% (1/17) and TTN was 0% (0/18). Malondialdehyde levels decreased observably in TTA group, and superoxide dismutase, catalase and glutathione peroxidase levels remained basically unaffected. Enzymatic scavenging of the intracellular superoxide at acupoints LI 20 produced efficacy in treating allergic rhinitis while no improvement was observed with the placebo group and TTN group.
Original languageEnglish
Article number3830273
Number of pages9
JournalEvidence-based complementary and alternative medicine
Volume2016
DOIs
Publication statusPublished - 15 Dec 2016

Keywords

  • Reactive oxygen species, Superoxide, TAT-Cu,Zn-superoxide dismutase, Acupoints, Allergic rhinitis

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