Total colonic dye-spray increases the detection of diminutive adenomas during routine colonoscopy: a randomized controlled trial

JC Brooker*, BP Saunders, SG Shah, CJ Thapar, HJW Thomas, WS Atkin, CR Cardwell, CB Williams

*Corresponding author for this work

Research output: Contribution to journalArticle

250 Citations (Scopus)


Background: Small adenomas may be missed during colonoscopy, but chromoscopy has been reported to enhance detection. The aim of this randomized-controlled trial was to determine the effect of total colonic dye spray on adenoma detection during routine colonoscopy.

Methods: Consecutive outpatients undergoing routine colonoscopy were randomized to a dye-spray group (0.1% indigo carmine used to coat the entire colon during withdrawal from the cecum) or control group (no dye).

Results: Two hundred fifty-nine patients were randomized, 124 to the dye-spray and 135 to the control group; demographics, indication for colonoscopy, and quality of the preparation were similar between the groups. Extubation from the cecum took a median of 9:05 minutes (range: 2:4824:44 min) in the dye-spray group versus 4:52 minutes (range: 1:42-15:21 min] in the control group (p <0.0001). The proportion of patients with at least 1 adenoma and the total number of adenomas were not different between groups. However, in the dye-spray group significantly more diminutive adenomas (

Conclusions: Dye-spray increases the detection of small adenomas in the proximal colon and patients with multiple adenomas, but long-term outcomes should be studied to determine the clinical value of these findings.

Original languageEnglish
Pages (from-to)333-338
Number of pages6
JournalGastrointestinal Endoscopy
Issue number3
Publication statusPublished - Sep 2002
EventDigestive Disease Week/101st Annual Meeting of the American-Gastroenterological-Association - SAN DIEGO, United States
Duration: 21 May 200024 May 2000



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