Total serum IL-12 and IL-12p40, but not IL-12p70, are increased in the serum of older subjects; relationship to CD3(+)and NK subsets

I M Rea; S E McNerlan; H D Alexander

doi:10.1006/cyto.1999.0537

Total serum IL-12 and IL-12p40, but not IL-12p70, are increased in the serum of older subjects; relationship to CD3(+)and NK subsets

I M Rea, S E McNerlan, H D Alexander

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

Abstract

Interleukin 12 (IL-12), a central cytokine acting on T and natural killer (NK) cells, directs proliferation of activated T lymphocytes towards a Th1 phenotype. The heterodimeric molecule IL-12p70, equates with IL-12 biological activity, while IL-12p40 may antagonize IL-12 and inhibit cytotoxic T lymphocyte (CTL) generation in vitro. This study characterizes age-related changes in serum total IL-12, IL-12p70 and IL-12p40 relating them with CD3(+), NK and related subsets from subjects, aged 30-96 years. Total IL-12, IL-12p40 and the IL-12p40/IL-12p70 ratio, but not IL-12p70, increased significantly with age (P

Original language	English
Pages (from-to)	156-9
Number of pages	4
Journal	Cytokine
Volume	12
Issue number	2
DOIs	https://doi.org/10.1006/cyto.1999.0537
Publication status	Published - Feb 2000

Bibliographical note

ASJC Scopus subject areas

Endocrinology
Molecular Biology
Immunology
Immunology and Allergy

Access to Document

10.1006/cyto.1999.0537

36 Citations
1 Article

Killer immunoglobulin-like Receptors (KIR) haplogroups A and B track with Natural Killer Cells and Cytokine Profile in Aged Subjects: Observations from Octo/Nonagenarians in the Belfast Elderly Longitudinal Free-living Aging STudy (BELFAST)
Rea, I. M., Maxwell, L. D., McNerlan, S. E., Alexander, H. D., Curran, M. D., Middleton, D. & Ross, O. A., Aug 2013, In: Immunity & ageing. 10, 12 p., 35.
Research output: Contribution to journal › Article › peer-review

Open Access
File
13 Citations (Scopus)

358 Downloads (Pure)

Cite this

@article{719d37002d464d92803d557ec5981bcf,

title = "Total serum IL-12 and IL-12p40, but not IL-12p70, are increased in the serum of older subjects; relationship to CD3(+)and NK subsets",

abstract = "Interleukin 12 (IL-12), a central cytokine acting on T and natural killer (NK) cells, directs proliferation of activated T lymphocytes towards a Th1 phenotype. The heterodimeric molecule IL-12p70, equates with IL-12 biological activity, while IL-12p40 may antagonize IL-12 and inhibit cytotoxic T lymphocyte (CTL) generation in vitro. This study characterizes age-related changes in serum total IL-12, IL-12p70 and IL-12p40 relating them with CD3(+), NK and related subsets from subjects, aged 30-96 years. Total IL-12, IL-12p40 and the IL-12p40/IL-12p70 ratio, but not IL-12p70, increased significantly with age (P",

author = "Rea, {I M} and McNerlan, {S E} and Alexander, {H D}",

year = "2000",

month = feb,

doi = "10.1006/cyto.1999.0537",

language = "English",

volume = "12",

pages = "156--9",

journal = "Cytokine",

issn = "1043-4666",

publisher = "Academic Press Inc.",

number = "2",

}

TY - JOUR

T1 - Total serum IL-12 and IL-12p40, but not IL-12p70, are increased in the serum of older subjects; relationship to CD3(+)and NK subsets

AU - Rea, I M

AU - McNerlan, S E

AU - Alexander, H D

PY - 2000/2

Y1 - 2000/2

N2 - Interleukin 12 (IL-12), a central cytokine acting on T and natural killer (NK) cells, directs proliferation of activated T lymphocytes towards a Th1 phenotype. The heterodimeric molecule IL-12p70, equates with IL-12 biological activity, while IL-12p40 may antagonize IL-12 and inhibit cytotoxic T lymphocyte (CTL) generation in vitro. This study characterizes age-related changes in serum total IL-12, IL-12p70 and IL-12p40 relating them with CD3(+), NK and related subsets from subjects, aged 30-96 years. Total IL-12, IL-12p40 and the IL-12p40/IL-12p70 ratio, but not IL-12p70, increased significantly with age (P

AB - Interleukin 12 (IL-12), a central cytokine acting on T and natural killer (NK) cells, directs proliferation of activated T lymphocytes towards a Th1 phenotype. The heterodimeric molecule IL-12p70, equates with IL-12 biological activity, while IL-12p40 may antagonize IL-12 and inhibit cytotoxic T lymphocyte (CTL) generation in vitro. This study characterizes age-related changes in serum total IL-12, IL-12p70 and IL-12p40 relating them with CD3(+), NK and related subsets from subjects, aged 30-96 years. Total IL-12, IL-12p40 and the IL-12p40/IL-12p70 ratio, but not IL-12p70, increased significantly with age (P

U2 - 10.1006/cyto.1999.0537

DO - 10.1006/cyto.1999.0537

M3 - Article

C2 - 10671301

SN - 1043-4666

VL - 12

SP - 156

EP - 159

JO - Cytokine

JF - Cytokine

IS - 2

ER -

Total serum IL-12 and IL-12p40, but not IL-12p70, are increased in the serum of older subjects; relationship to CD3(+)and NK subsets

Abstract

Bibliographical note

ASJC Scopus subject areas

Access to Document

Fingerprint

Research output

Killer immunoglobulin-like Receptors (KIR) haplogroups A and B track with Natural Killer Cells and Cytokine Profile in Aged Subjects: Observations from Octo/Nonagenarians in the Belfast Elderly Longitudinal Free-living Aging STudy (BELFAST)

Cite this