Total synthesis of (+)-A83586C, (+)-kettapeptin and (+)-azinothricin: powerful new inhibitors of β-catenin/TCF4-and E2F-mediated gene transcription

Karl J. Hale; Soraya Manaviazar; Jonathan George

doi:10.1039/c000603c

Total synthesis of (+)-A83586C, (+)-kettapeptin and (+)-azinothricin: powerful new inhibitors of β-catenin/TCF4-and E2F-mediated gene transcription

Karl J. Hale, Soraya Manaviazar, Jonathan George

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

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Abstract

Herein we describe our asymmetric total syntheses of (+)-A83586C, (+)-kettapeptin and (+)-azinothricin. We also demonstrate that molecules of this class powerfully inhibit β-catenin/TCF4- and E2F-mediated gene transcription within malignant human colon cancer cells at low drug concentrations.

Original language	English
Pages (from-to)	4021-4042
Number of pages	22
Journal	Chemical Communications
Volume	46
Issue number	23
Early online date	19 Apr 2010
DOIs	https://doi.org/10.1039/c000603c
Publication status	Published - 21 Jun 2010

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Ceramics and Composites
Electronic, Optical and Magnetic Materials
Materials Chemistry
Metals and Alloys
Surfaces, Coatings and Films

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title = "Total synthesis of (+)-A83586C, (+)-kettapeptin and (+)-azinothricin: powerful new inhibitors of β-catenin/TCF4-and E2F-mediated gene transcription",

abstract = "Herein we describe our asymmetric total syntheses of (+)-A83586C, (+)-kettapeptin and (+)-azinothricin. We also demonstrate that molecules of this class powerfully inhibit β-catenin/TCF4- and E2F-mediated gene transcription within malignant human colon cancer cells at low drug concentrations.",

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AU - Hale, Karl J.

AU - Manaviazar, Soraya

AU - George, Jonathan

PY - 2010/6/21

Y1 - 2010/6/21

N2 - Herein we describe our asymmetric total syntheses of (+)-A83586C, (+)-kettapeptin and (+)-azinothricin. We also demonstrate that molecules of this class powerfully inhibit β-catenin/TCF4- and E2F-mediated gene transcription within malignant human colon cancer cells at low drug concentrations.

AB - Herein we describe our asymmetric total syntheses of (+)-A83586C, (+)-kettapeptin and (+)-azinothricin. We also demonstrate that molecules of this class powerfully inhibit β-catenin/TCF4- and E2F-mediated gene transcription within malignant human colon cancer cells at low drug concentrations.

U2 - 10.1039/c000603c

DO - 10.1039/c000603c

M3 - Article

VL - 46

SP - 4021

EP - 4042

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 23

ER -

Total synthesis of (+)-A83586C, (+)-kettapeptin and (+)-azinothricin: powerful new inhibitors of β-catenin/TCF4-and E2F-mediated gene transcription

Abstract

ASJC Scopus subject areas

UN SDGs

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