Toward automatic reconstruction of a highly resolved tree of life

Francesca D. Ciccarelli, Tobias Doerks, Christian Von Mering, Christopher J. Creevey, Berend Snel, Peer Bork*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1080 Citations (Scopus)


We have developed an automatable procedure for reconstructing the tree of life with branch lengths comparable across all three domains. The tree has its basis in a concatenation of 31 orthologs occurring in 191 species with sequenced genomes. It revealed interdomain discrepancies in taxonomic classification. Systematic detection and subsequent exclusion of products of horizontal gene transfer increased phylogenetic resolution, allowing us to confirm accepted relationships and resolve disputed and preliminary classifications. For example, we place the phylum Addobacteria as a sister group of δ-Proteobacteria, support a Gram-positive origin of Bacteria, and suggest a thermophilic last universal common ancestor.

Original languageEnglish
Pages (from-to)1283-1287
Number of pages5
Issue number5765
Publication statusPublished - 03 Mar 2006
Externally publishedYes

ASJC Scopus subject areas

  • General


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