TY - JOUR
T1 - Toward automatic reconstruction of a highly resolved tree of life
AU - Ciccarelli, Francesca D.
AU - Doerks, Tobias
AU - Von Mering, Christian
AU - Creevey, Christopher J.
AU - Snel, Berend
AU - Bork, Peer
PY - 2006/3/3
Y1 - 2006/3/3
N2 - We have developed an automatable procedure for reconstructing the tree of life with branch lengths comparable across all three domains. The tree has its basis in a concatenation of 31 orthologs occurring in 191 species with sequenced genomes. It revealed interdomain discrepancies in taxonomic classification. Systematic detection and subsequent exclusion of products of horizontal gene transfer increased phylogenetic resolution, allowing us to confirm accepted relationships and resolve disputed and preliminary classifications. For example, we place the phylum Addobacteria as a sister group of δ-Proteobacteria, support a Gram-positive origin of Bacteria, and suggest a thermophilic last universal common ancestor.
AB - We have developed an automatable procedure for reconstructing the tree of life with branch lengths comparable across all three domains. The tree has its basis in a concatenation of 31 orthologs occurring in 191 species with sequenced genomes. It revealed interdomain discrepancies in taxonomic classification. Systematic detection and subsequent exclusion of products of horizontal gene transfer increased phylogenetic resolution, allowing us to confirm accepted relationships and resolve disputed and preliminary classifications. For example, we place the phylum Addobacteria as a sister group of δ-Proteobacteria, support a Gram-positive origin of Bacteria, and suggest a thermophilic last universal common ancestor.
UR - http://www.scopus.com/inward/record.url?scp=33644700003&partnerID=8YFLogxK
U2 - 10.1126/science.1123061
DO - 10.1126/science.1123061
M3 - Article
C2 - 16513982
AN - SCOPUS:33644700003
SN - 0036-8075
VL - 311
SP - 1283
EP - 1287
JO - Science
JF - Science
IS - 5765
ER -