Towards a reliable neural biomarker for predicting response to non-invasive brain stimulation in the treatment of depression

Emmet McNickle, Lamia Tadjine, Kathy Ruddy*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

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Abstract

Non-invasive brain stimulation (NIBS) approaches such as repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) are rapidly emerging as effective and well-tolerated treatments for depression. With the most recent head-to-head studies demonstrating equivalence in clinical efficacy between rTMS, tDCS and widely used pharmaceutical antidepressants, there is urgent need for a paradigm shift towards its inclusion as a low-cost, low-risk frontline treatment for depression. Here, we provide a narrative review outlining barriers currently impeding translation of NIBS approaches into large-scale clinical use, with a view to developing a neural biomarker that could provide early stratification of patients as potential responders or non-responders. We describe how the TMS-evoked potential provides a marker of cortical excitability that could be used as a baseline predictor of whether the NIBS user will derive benefit from approaches tailored to achieve neuromodulation.

Original languageEnglish
Article number101369
Number of pages5
JournalCurrent Opinion in Behavioral Sciences
Volume56
Early online date07 Mar 2024
DOIs
Publication statusPublished - Apr 2024

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