Towards answering questions in disorders of consciousness and locked-in syndrome with a SMR-BCI

Natalie Dayan; Alain Bigirimana; Alison McCann; Jacqueline Stow; Jacinta McElligott; Aine Carroll; Damien Coyle

doi:10.3217/978-3-85125-682-6-65

Towards answering questions in disorders of consciousness and locked-in syndrome with a SMR-BCI

Natalie Dayan, Alain Bigirimana, Alison McCann, Jacqueline Stow, Jacinta McElligott, Aine Carroll, Damien Coyle

Research output: Chapter in Book/Report/Conference proceeding › Chapter

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Abstract

Sensorimotor rhythm-based brain computer interfaces (SMR-BCI) may enable patients with prolonged disorders of consciousness (PDoC) or severe physical impairment to learn to intentionally modulate motor cortical neural oscillations. SMR-BCI could mitigate the need for movement-dependent behavioural responses, hence providing diagnostic information and/or communication strategies. Here, an SMR-BCI was evaluated in a three-staged protocol for PDoC. Stage I assessed awareness and capacity to modulate brain activity intentionally. Stage II facilitated SMR-BCI learning via stereo-auditory feedback training. Stage III tested use of SMR-BCI to answer closed categorized yes/no questions. Out of 14 patients with PDoC and locked in syndrome (LIS), eight patients showed capacity to modulate brain activity during stage I and thus participated in stage II. For practical reasons only five of these patients completed stage III. Two able-bodied participants were enrolled for benchmarking. Five of the eight participants performed significantly greater than chance level in 50-100% of runs (p<0.05). Average top run performance accuracy correlated with diagnoses category. Participants across the PDoC spectrum showed capacity to engage with SMR-BCI to answer closed questions.

Original language	English
Title of host publication	Proceedings of the 8th Graz Brain Computer Interface Conference 2019: bridging science and application
Editors	Gernot Müller-Putz, Jonas Christian Ditz, Selina Wriessnegger
Publisher	Technische Universität Graz
ISBN (Electronic)	9783851256826
DOIs	https://doi.org/10.3217/978-3-85125-682-6-65
Publication status	Published - 20 Sept 2019
Externally published	Yes

Publication series

Name	Proceedings of the Graz Brain-Computer Interface Conference
ISSN (Print)	2311-0422

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10.3217/978-3-85125-682-6-65Licence: CC BY-ND

Towards answering questions in disorders of consciousness and locked-in syndrome with a SMR-BCI
Copyright 2019 The Authors. This is an open access article published under a Creative Commons Attribution-NoDerivs License (https://creativecommons.org/licenses/by-nd/4.0/), which permits reproduction and redistribute in any medium, provided the author and source are cited and any subsequent modifications are not distributed.
Final published version, 2.65 MBLicence: CC BY-ND

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Dayan, N., Bigirimana, A., McCann, A., Stow, J., McElligott, J., Carroll, A., & Coyle, D. (2019). Towards answering questions in disorders of consciousness and locked-in syndrome with a SMR-BCI. In G. Müller-Putz, J. C. Ditz, & S. Wriessnegger (Eds.), Proceedings of the 8th Graz Brain Computer Interface Conference 2019: bridging science and application (Proceedings of the Graz Brain-Computer Interface Conference). Technische Universität Graz. https://doi.org/10.3217/978-3-85125-682-6-65

Dayan, Natalie ; Bigirimana, Alain ; McCann, Alison et al. / Towards answering questions in disorders of consciousness and locked-in syndrome with a SMR-BCI. Proceedings of the 8th Graz Brain Computer Interface Conference 2019: bridging science and application. editor / Gernot Müller-Putz ; Jonas Christian Ditz ; Selina Wriessnegger. Technische Universität Graz, 2019. (Proceedings of the Graz Brain-Computer Interface Conference).

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abstract = "Sensorimotor rhythm-based brain computer interfaces (SMR-BCI) may enable patients with prolonged disorders of consciousness (PDoC) or severe physical impairment to learn to intentionally modulate motor cortical neural oscillations. SMR-BCI could mitigate the need for movement-dependent behavioural responses, hence providing diagnostic information and/or communication strategies. Here, an SMR-BCI was evaluated in a three-staged protocol for PDoC. Stage I assessed awareness and capacity to modulate brain activity intentionally. Stage II facilitated SMR-BCI learning via stereo-auditory feedback training. Stage III tested use of SMR-BCI to answer closed categorized yes/no questions. Out of 14 patients with PDoC and locked in syndrome (LIS), eight patients showed capacity to modulate brain activity during stage I and thus participated in stage II. For practical reasons only five of these patients completed stage III. Two able-bodied participants were enrolled for benchmarking. Five of the eight participants performed significantly greater than chance level in 50-100% of runs (p<0.05). Average top run performance accuracy correlated with diagnoses category. Participants across the PDoC spectrum showed capacity to engage with SMR-BCI to answer closed questions.",

author = "Natalie Dayan and Alain Bigirimana and Alison McCann and Jacqueline Stow and Jacinta McElligott and Aine Carroll and Damien Coyle",

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Dayan, N, Bigirimana, A, McCann, A, Stow, J, McElligott, J, Carroll, A & Coyle, D 2019, Towards answering questions in disorders of consciousness and locked-in syndrome with a SMR-BCI. in G Müller-Putz, JC Ditz & S Wriessnegger (eds), Proceedings of the 8th Graz Brain Computer Interface Conference 2019: bridging science and application. Proceedings of the Graz Brain-Computer Interface Conference, Technische Universität Graz. https://doi.org/10.3217/978-3-85125-682-6-65

Towards answering questions in disorders of consciousness and locked-in syndrome with a SMR-BCI. / Dayan, Natalie; Bigirimana, Alain; McCann, Alison et al.
Proceedings of the 8th Graz Brain Computer Interface Conference 2019: bridging science and application. ed. / Gernot Müller-Putz; Jonas Christian Ditz; Selina Wriessnegger. Technische Universität Graz, 2019. (Proceedings of the Graz Brain-Computer Interface Conference).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

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AU - Carroll, Aine

AU - Coyle, Damien

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AB - Sensorimotor rhythm-based brain computer interfaces (SMR-BCI) may enable patients with prolonged disorders of consciousness (PDoC) or severe physical impairment to learn to intentionally modulate motor cortical neural oscillations. SMR-BCI could mitigate the need for movement-dependent behavioural responses, hence providing diagnostic information and/or communication strategies. Here, an SMR-BCI was evaluated in a three-staged protocol for PDoC. Stage I assessed awareness and capacity to modulate brain activity intentionally. Stage II facilitated SMR-BCI learning via stereo-auditory feedback training. Stage III tested use of SMR-BCI to answer closed categorized yes/no questions. Out of 14 patients with PDoC and locked in syndrome (LIS), eight patients showed capacity to modulate brain activity during stage I and thus participated in stage II. For practical reasons only five of these patients completed stage III. Two able-bodied participants were enrolled for benchmarking. Five of the eight participants performed significantly greater than chance level in 50-100% of runs (p<0.05). Average top run performance accuracy correlated with diagnoses category. Participants across the PDoC spectrum showed capacity to engage with SMR-BCI to answer closed questions.

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PB - Technische Universität Graz

ER -

Dayan N, Bigirimana A, McCann A, Stow J, McElligott J, Carroll A et al. Towards answering questions in disorders of consciousness and locked-in syndrome with a SMR-BCI. In Müller-Putz G, Ditz JC, Wriessnegger S, editors, Proceedings of the 8th Graz Brain Computer Interface Conference 2019: bridging science and application. Technische Universität Graz. 2019. (Proceedings of the Graz Brain-Computer Interface Conference). doi: 10.3217/978-3-85125-682-6-65

Towards answering questions in disorders of consciousness and locked-in syndrome with a SMR-BCI

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