Towards Surface Plasmon Resonance biosensing combined with bioaffinity-assisted nano HILIC Liquid Chromatography Time-of-flight Mass Spectrometry identification of Paralytic Shellfish Poisons

G.R. Marchesini, H. Hooijerink, W. Haasnoot, J. Buijs, K. Campbell, Christopher Elliott, M.W.F. Nielen

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

The potential for coupling technologies to deliver new, improved forms of bioanalysis is still in its infancy. We review a number of examples in which coupling has been successful, with special emphasis on combining surface-plasmon-resonance biosensors with mass spectrometry. We give an overview of current progress towards combining biosensor-based bioanalysis with chemical analysis for confirmation of paralytic shellfish poisons that are marine toxins. This comprehensive approach could be an alternative to the official methods currently used (e.g., animal testing and high-performance liquid chromatography with fluorescence detection) and could serve as a model for many more such applications. (C) 2009 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)792-803
Number of pages12
JournalTRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume28
Issue number6
DOIs
Publication statusPublished - Jun 2009

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy
  • Environmental Chemistry

Fingerprint

Dive into the research topics of 'Towards Surface Plasmon Resonance biosensing combined with bioaffinity-assisted nano HILIC Liquid Chromatography Time-of-flight Mass Spectrometry identification of Paralytic Shellfish Poisons'. Together they form a unique fingerprint.

Cite this