Toxic, but beneficial compounds from endophytic fungi of Carica papaya

Peter M. Eze; Dominic O. Abonyi; Chika C. Abba; Peter Proksch; Festus B. C. Okoye; Charles O. Esimone

doi:10.2478/ebtj-2019-0012

Toxic, but beneficial compounds from endophytic fungi of Carica papaya

Peter M. Eze^*, Dominic O. Abonyi, Chika C. Abba, Peter Proksch, Festus B. C. Okoye, Charles O. Esimone

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Fungi remain a promising source of novel biologically active compounds with potentials in drug discovery and development. This study was aimed at investigating the secondary metabolites from endophytic Fusarium equiseti and Epicoccum sorghinum associated with leaves of Carica papaya collected from Agulu, Anambra State, Nigeria. Isolation of the endophytic fungi, taxonomic identification, fermentation, extraction and isolation of fungal secondary metabolites were carried out using standard procedures. Chromatographic separation and spectroscopic analyses of the fungal secondary metabolites yielded three toxigenic compounds - equisetin and its epimer 5’- epiequisetin from F. equiseti and tenuazonic acid from E. sorghinum These compounds are known to possess several beneficial biological properties that can be explored for pharmaceutical, agricultural or industrial purposes.

Original language	English
Pages (from-to)	105-111
Number of pages	7
Journal	The EuroBiotech Journal
Volume	3
Issue number	2
DOIs	https://doi.org/10.2478/ebtj-2019-0012
Publication status	Published - 01 Apr 2019
Externally published	Yes

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Toxic, but beneficial compounds from endophytic fungi of Carica papaya
Copyright 2019the authors. This is an open access article published under a Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits distribution and reproduction for non-commercial purposes, provided the author and source are cited.
Final published version, 394 KBLicence: CC BY-NC-ND

Cite this

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title = "Toxic, but beneficial compounds from endophytic fungi of Carica papaya",

abstract = " Fungi remain a promising source of novel biologically active compounds with potentials in drug discovery and development. This study was aimed at investigating the secondary metabolites from endophytic Fusarium equiseti and Epicoccum sorghinum associated with leaves of Carica papaya collected from Agulu, Anambra State, Nigeria. Isolation of the endophytic fungi, taxonomic identification, fermentation, extraction and isolation of fungal secondary metabolites were carried out using standard procedures. Chromatographic separation and spectroscopic analyses of the fungal secondary metabolites yielded three toxigenic compounds - equisetin and its epimer 5{\textquoteright}- epiequisetin from F. equiseti and tenuazonic acid from E. sorghinum These compounds are known to possess several beneficial biological properties that can be explored for pharmaceutical, agricultural or industrial purposes. ",

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AU - Eze, Peter M.

AU - Abonyi, Dominic O.

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AU - Okoye, Festus B. C.

AU - Esimone, Charles O.

PY - 2019/4/1

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N2 - Fungi remain a promising source of novel biologically active compounds with potentials in drug discovery and development. This study was aimed at investigating the secondary metabolites from endophytic Fusarium equiseti and Epicoccum sorghinum associated with leaves of Carica papaya collected from Agulu, Anambra State, Nigeria. Isolation of the endophytic fungi, taxonomic identification, fermentation, extraction and isolation of fungal secondary metabolites were carried out using standard procedures. Chromatographic separation and spectroscopic analyses of the fungal secondary metabolites yielded three toxigenic compounds - equisetin and its epimer 5’- epiequisetin from F. equiseti and tenuazonic acid from E. sorghinum These compounds are known to possess several beneficial biological properties that can be explored for pharmaceutical, agricultural or industrial purposes.

AB - Fungi remain a promising source of novel biologically active compounds with potentials in drug discovery and development. This study was aimed at investigating the secondary metabolites from endophytic Fusarium equiseti and Epicoccum sorghinum associated with leaves of Carica papaya collected from Agulu, Anambra State, Nigeria. Isolation of the endophytic fungi, taxonomic identification, fermentation, extraction and isolation of fungal secondary metabolites were carried out using standard procedures. Chromatographic separation and spectroscopic analyses of the fungal secondary metabolites yielded three toxigenic compounds - equisetin and its epimer 5’- epiequisetin from F. equiseti and tenuazonic acid from E. sorghinum These compounds are known to possess several beneficial biological properties that can be explored for pharmaceutical, agricultural or industrial purposes.

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DO - 10.2478/ebtj-2019-0012

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Toxic, but beneficial compounds from endophytic fungi of Carica papaya

Abstract

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