Trace Element Abundance and Renal Disease

Chloe Floyd, Jennifer McKinley, Ulrich Ofterdinger, Damian Fogarty, Peter Atkinson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This research investigates the relationship between elevated trace elements in soils, stream sediments and stream water and the prevalence of Chronic Kidney Disease (CKD). The study uses a collaboration of datasets provided from the UK Renal Registry Report (UKRR) on patients with renal diseases requiring treatment including Renal Replacement Therapy (RRT), the soil geochemical dataset for Northern Ireland provided by the Tellus Survey, Geological Survey of Northern Ireland (GSNI) and the bioaccessibility of Potentially Toxic Elements (PTEs) from soil samples which were obtained from the Unified Barge Method (UBM). The relationship between these factors derives from the UKRR report which highlights incidence rates of renal impaired patients showing regional variation with cases of unknown aetiology. Studies suggest a potential cause of the large variation and uncertain aetiology is associated with underlying environmental factors such as the oral bioaccessibility of trace elements in the gastrointestinal tract.
As previous research indicates that long term exposure is related to environmental factors, Northern Ireland is ideally placed for this research as people traditionally live in the same location for long periods of time. Exploratory data analysis and multivariate analyses are used to examine the soil, stream sediments and stream water geochemistry data for a range of key elements including arsenic, lead, cadmium and mercury identified from a review of previous renal disease literature. The spatial prevalence of patients with long term CKD is analysed on an area basis. Further work includes cluster analysis to detect areas of low or high incidences of CKD that are significantly correlated in space, Geographical Weighted Regression (GWR) and Poisson kriging to examine locally varying relationship between elevated concentrations of PTEs and the prevalence of CKD.
Original languageEnglish
Title of host publicationGeostatistics For Environmental Applications: geoEnv 2014
EditorsNicolas Jeannee, Thomas Romary
Place of PublicationParis, France
PublisherPresses de MINES
Pages58
Number of pages1
ISBN (Print)9782356711366
Publication statusPublished - 09 Jul 2014
EventGeoEnv 2014 - France, Paris, France
Duration: 07 Jul 201411 Jul 2014

Publication series

NameCollection Sciences de la terre et de l'environment
PublisherPresses des MINES

Conference

ConferenceGeoEnv 2014
CountryFrance
CityParis
Period07/07/201411/07/2014

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    Floyd, C., McKinley, J., Ofterdinger, U., Fogarty, D., & Atkinson, P. (2014). Trace Element Abundance and Renal Disease. In N. Jeannee, & T. Romary (Eds.), Geostatistics For Environmental Applications: geoEnv 2014 (pp. 58). (Collection Sciences de la terre et de l'environment). Presses de MINES. http://www.pressesdesmines.com/sciences-de-la-terre-et-de-l-environnement-1/geostatistics-for-environmental-applications.html