Transamidation reactions of  -lactams: a synthesis of ( )-dihydroperiphylline.

L. Crombie, David Haigh, R.C.F. Jones

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


Ammonolysis of N-(halogenoalkyl)azetidin-2-ones affords medium ring azalactams via transamidation but large or strained rings are not isolated, acyclic ?-amino-amides being produced; two successive transamidative ring expansions from 4-phenylazetidin-2-one give a synthesis of (?)-dihydroperiphylline (I).
Original languageEnglish
Pages (from-to)5151-5154
Number of pages4
JournalTetrahedron Letters
Publication statusPublished - 1986


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