Transcription-independent function of polycomb group protein PSC in cell cycle control

Adone Tielenius Kruythoff-Mohd Sarip, Anna Lagarou, Cecile M. Doyen, Jan A. Van Der Knaap, Ülkü Aslan, Karel Bezstarosti, Yasmin Yassin, Hugh W. Brock, Jeroen A. Demmers, C. Peter Verrijzer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)

Abstract

Polycomb group (PcG) proteins control development and cell proliferation through chromatin-mediated transcriptional repression. We describe a transcription-independent function for PcG protein Posterior sex combs (PSC) in regulating the destruction of cyclin B (CYC-B). A substantial portion of PSC was found outside canonical PcG complexes, instead associated with CYC-B and the anaphase-promoting complex (APC). Cell-based experiments and reconstituted reactions established that PSC and Lemming (LMG, also called APC11) associate and ubiquitylate CYC-B cooperatively, marking it for proteosomal degradation. Thus, PSC appears to mediate both developmental gene silencing and posttranslational control of mitosis. Direct regulation of cell cycle progression might be a crucial part of the PcG system's function in development and cancer.

Original languageEnglish
Pages (from-to)744-747
Number of pages4
JournalScience
Volume336
Issue number6082
DOIs
Publication statusPublished - 11 May 2012

ASJC Scopus subject areas

  • Medicine(all)
  • General

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