Transcriptional responses of Burkholderia cenocepacia to polymyxin B in isogenic strains with diverse polymyxin B resistance phenotypes

S.A. Loutet, F. Di Lorenzo, C. Clarke, A. Molinaro, Miguel Valvano

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: Burkholderia cenocepacia is a Gram-negative opportunistic pathogen displaying high resistance to antimicrobial peptides and polymyxins. We identified mechanisms of resistance by analyzing transcriptional changes to polymyxin B treatment in three isogenic B. cenocepacia strains with diverse polymyxin B resistance phenotypes: the polymyxin B-resistant parental strain K56-2, a polymyxin B-sensitive K56-2 mutant strain with heptoseless lipopolysaccharide (LPS) (RSF34), and a derivative of RSF34 (RSF34 4000B) isolated through multiple rounds of selection in polymyxin B that despite having a heptoseless LPS is highly polymyxin B-resistant.
Original languageEnglish
Article number472
JournalBMC Genomics
Volume12
DOIs
Publication statusPublished - 29 Sep 2011

ASJC Scopus subject areas

  • Biotechnology
  • Genetics

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