Transdermal Delivery of Iron Using Soluble Microneedles: Dermal Kinetics and Safety

Naresh Modepalli, H. Nanjappa Shivakumar, Maeliosa T.C. McCrudden, Ryan F. Donnelly, Ajay Banga, S. Narasimha Murthy*

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Currently, the iron compounds are administered via oral and parenteral routes in patients of all ages, to treat iron deficiency. Despite continued efforts to supplement iron via these conventional routes, iron deficiency still remains the most prevalent nutritional disorder all over the world. Transdermal replenishment of iron is a novel, potential approach of iron replenishment. Ferric pyrophosphate (FPP) was found to be a suitable source of iron for transdermal replenishment. The safety of FPP was assessed in this project by challenging the dermal fibroblast cells with high concentration of FPP. The cell viability assay and reactive oxygen species assay were performed. The soluble microneedle array was developed, incorporated with FPP and the kinetics of free iron in the skin; extracellular fluid following dermal administration of microneedle array was investigated in hairless rats. From the cell based assays, FPP was selected as one of the potential iron sources for transdermal delivery. The microneedles were found to dissolve in the skin fluid within 3 hours of administration. The FPP concentration in the dermal extracellular fluid declined after complete dissolution of the microneedle array. Overall, the studies demonstrated the safety of FPP for dermal delivery and the feasibility of soluble microneedle approach for transdermal iron replenishment therapy.

Original languageEnglish
Pages (from-to)1196-1200
JournalJournal of Pharmaceutical Sciences
Volume105
Issue number3
DOIs
Publication statusPublished - 01 Mar 2016

Keywords

  • cell lines
  • kinetics
  • microarrays
  • microdialysis
  • reactive oxygen species
  • skin
  • transdermal drug delivery

ASJC Scopus subject areas

  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'Transdermal Delivery of Iron Using Soluble Microneedles: Dermal Kinetics and Safety'. Together they form a unique fingerprint.

Cite this