Transdermal drug delivery: Innovative pharmaceutical developments based on disruption of the barrier properties of the stratum corneum

Ahlam Zaid Alkilani*, Maelíosa T.C. McCrudden, Ryan F. Donnelly

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

198 Citations (Scopus)
59 Downloads (Pure)

Abstract

The skin offers an accessible and convenient site for the administration of medications. To this end, the field of transdermal drug delivery, aimed at developing safe and efficacious means of delivering medications across the skin, has in the past and continues to garner much time and investment with the continuous advancement of new and innovative approaches. This review details the progress and current status of the transdermal drug delivery field and describes numerous pharmaceutical developments which have been employed to overcome limitations associated with skin delivery systems. Advantages and disadvantages of the various approaches are detailed, commercially marketed products are highlighted and particular attention is paid to the emerging field of microneedle technologies.

Original languageEnglish
Pages (from-to)438-470
Number of pages33
JournalPharmaceutics
Volume7
Issue number4
DOIs
Publication statusPublished - 22 Oct 2015

Keywords

  • Drug delivery
  • Mechanical and electrical approaches
  • Microneedle
  • Thermal ablation
  • Transdermal
  • Ultrasound
  • Velocity based device

ASJC Scopus subject areas

  • Pharmaceutical Science

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