Transdermal drug delivery: Innovative pharmaceutical developments based on disruption of the barrier properties of the stratum corneum

Ahlam Zaid Alkilani; Maelíosa T.C. McCrudden; Ryan F. Donnelly

doi:10.3390/pharmaceutics7040438

Transdermal drug delivery: Innovative pharmaceutical developments based on disruption of the barrier properties of the stratum corneum

Ahlam Zaid Alkilani^*, Maelíosa T.C. McCrudden, Ryan F. Donnelly

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Review article › peer-review

275 Citations (Scopus)

109 Downloads (Pure)

Abstract

The skin offers an accessible and convenient site for the administration of medications. To this end, the field of transdermal drug delivery, aimed at developing safe and efficacious means of delivering medications across the skin, has in the past and continues to garner much time and investment with the continuous advancement of new and innovative approaches. This review details the progress and current status of the transdermal drug delivery field and describes numerous pharmaceutical developments which have been employed to overcome limitations associated with skin delivery systems. Advantages and disadvantages of the various approaches are detailed, commercially marketed products are highlighted and particular attention is paid to the emerging field of microneedle technologies.

Original language	English
Pages (from-to)	438-470
Number of pages	33
Journal	Pharmaceutics
Volume	7
Issue number	4
DOIs	https://doi.org/10.3390/pharmaceutics7040438
Publication status	Published - 22 Oct 2015

Keywords

Drug delivery
Mechanical and electrical approaches
Microneedle
Thermal ablation
Transdermal
Ultrasound
Velocity based device

ASJC Scopus subject areas

Pharmaceutical Science

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10.3390/pharmaceutics7040438Licence: CC BY

Transdermal Drug Delivery: Innovative Pharmaceutical Developments Based on Disruption of the Barrier Properties of the Stratum Corneum
Copyright 2015 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 3.23 MBLicence: CC BY

Cite this

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abstract = "The skin offers an accessible and convenient site for the administration of medications. To this end, the field of transdermal drug delivery, aimed at developing safe and efficacious means of delivering medications across the skin, has in the past and continues to garner much time and investment with the continuous advancement of new and innovative approaches. This review details the progress and current status of the transdermal drug delivery field and describes numerous pharmaceutical developments which have been employed to overcome limitations associated with skin delivery systems. Advantages and disadvantages of the various approaches are detailed, commercially marketed products are highlighted and particular attention is paid to the emerging field of microneedle technologies.",

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Transdermal drug delivery: Innovative pharmaceutical developments based on disruption of the barrier properties of the stratum corneum

Abstract

Keywords

ASJC Scopus subject areas

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