Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation

Romina Nassini; Pamela Pedretti; Nadia Moretto; Camilla Fusi; Chiara Carnini; Fabrizio Facchinetti; Arturo Roberto Viscomi; Anna Rita Pisano; Susan Stokesberry; Charlott Brunmark; Naila Svitacheva; Lorcan McGarvey; Riccardo Patacchini; Anders B Damholt; Pierangelo Geppetti; Serena Materazzi

doi:10.1371/journal.pone.0042454

Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation

Romina Nassini, Pamela Pedretti, Nadia Moretto, Camilla Fusi, Chiara Carnini, Fabrizio Facchinetti, Arturo Roberto Viscomi, Anna Rita Pisano, Susan Stokesberry, Charlott Brunmark, Naila Svitacheva, Lorcan McGarvey, Riccardo Patacchini, Anders B Damholt, Pierangelo Geppetti, Serena Materazzi

Research output: Contribution to journal › Article › peer-review

132 Citations (Scopus)

Abstract

The transient receptor potential ankyrin 1 (TRPA1) channel, localized to airway sensory nerves, has been proposed to mediate airway inflammation evoked by allergen and cigarette smoke (CS) in rodents, via a neurogenic mechanism. However the limited clinical evidence for the role of neurogenic inflammation in asthma or chronic obstructive pulmonary disease raises an alternative possibility that airway inflammation is promoted by non-neuronal TRPA1.

Original language	English
Article number	e42454
Pages (from-to)	e42454
Journal	PLoS ONE
Volume	7
Issue number	8
DOIs	https://doi.org/10.1371/journal.pone.0042454
Publication status	Published - 14 Aug 2012

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

Access to Document

10.1371/journal.pone.0042454

Fingerprint Dive into the research topics of 'Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation'. Together they form a unique fingerprint.

Cite this

Nassini, R., Pedretti, P., Moretto, N., Fusi, C., Carnini, C., Facchinetti, F., Viscomi, A. R., Pisano, A. R., Stokesberry, S., Brunmark, C., Svitacheva, N., McGarvey, L., Patacchini, R., Damholt, A. B., Geppetti, P., & Materazzi, S. (2012). Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation. PLoS ONE, 7(8), e42454. [e42454]. https://doi.org/10.1371/journal.pone.0042454

Nassini, Romina ; Pedretti, Pamela ; Moretto, Nadia ; Fusi, Camilla ; Carnini, Chiara ; Facchinetti, Fabrizio ; Viscomi, Arturo Roberto ; Pisano, Anna Rita ; Stokesberry, Susan ; Brunmark, Charlott ; Svitacheva, Naila ; McGarvey, Lorcan ; Patacchini, Riccardo ; Damholt, Anders B ; Geppetti, Pierangelo ; Materazzi, Serena. / Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation. In: PLoS ONE. 2012 ; Vol. 7, No. 8. pp. e42454.

@article{453b7f4a2477482484cb2c6d3a6d3bb6,

title = "Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation",

abstract = "The transient receptor potential ankyrin 1 (TRPA1) channel, localized to airway sensory nerves, has been proposed to mediate airway inflammation evoked by allergen and cigarette smoke (CS) in rodents, via a neurogenic mechanism. However the limited clinical evidence for the role of neurogenic inflammation in asthma or chronic obstructive pulmonary disease raises an alternative possibility that airway inflammation is promoted by non-neuronal TRPA1.",

author = "Romina Nassini and Pamela Pedretti and Nadia Moretto and Camilla Fusi and Chiara Carnini and Fabrizio Facchinetti and Viscomi, {Arturo Roberto} and Pisano, {Anna Rita} and Susan Stokesberry and Charlott Brunmark and Naila Svitacheva and Lorcan McGarvey and Riccardo Patacchini and Damholt, {Anders B} and Pierangelo Geppetti and Serena Materazzi",

year = "2012",

month = aug,

day = "14",

doi = "10.1371/journal.pone.0042454",

language = "English",

volume = "7",

pages = "e42454",

journal = "PLoS One",

issn = "1932-6203",

publisher = "Public Library of Science (PLOS)",

number = "8",

}

Nassini, R, Pedretti, P, Moretto, N, Fusi, C, Carnini, C, Facchinetti, F, Viscomi, AR, Pisano, AR, Stokesberry, S, Brunmark, C, Svitacheva, N, McGarvey, L, Patacchini, R, Damholt, AB, Geppetti, P & Materazzi, S 2012, 'Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation', PLoS ONE, vol. 7, no. 8, e42454, pp. e42454. https://doi.org/10.1371/journal.pone.0042454

Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation. / Nassini, Romina; Pedretti, Pamela; Moretto, Nadia; Fusi, Camilla; Carnini, Chiara; Facchinetti, Fabrizio; Viscomi, Arturo Roberto; Pisano, Anna Rita; Stokesberry, Susan; Brunmark, Charlott; Svitacheva, Naila; McGarvey, Lorcan; Patacchini, Riccardo; Damholt, Anders B; Geppetti, Pierangelo; Materazzi, Serena.

In: PLoS ONE, Vol. 7, No. 8, e42454, 14.08.2012, p. e42454.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation

AU - Nassini, Romina

AU - Pedretti, Pamela

AU - Moretto, Nadia

AU - Fusi, Camilla

AU - Carnini, Chiara

AU - Facchinetti, Fabrizio

AU - Viscomi, Arturo Roberto

AU - Pisano, Anna Rita

AU - Stokesberry, Susan

AU - Brunmark, Charlott

AU - Svitacheva, Naila

AU - McGarvey, Lorcan

AU - Patacchini, Riccardo

AU - Damholt, Anders B

AU - Geppetti, Pierangelo

AU - Materazzi, Serena

PY - 2012/8/14

Y1 - 2012/8/14

N2 - The transient receptor potential ankyrin 1 (TRPA1) channel, localized to airway sensory nerves, has been proposed to mediate airway inflammation evoked by allergen and cigarette smoke (CS) in rodents, via a neurogenic mechanism. However the limited clinical evidence for the role of neurogenic inflammation in asthma or chronic obstructive pulmonary disease raises an alternative possibility that airway inflammation is promoted by non-neuronal TRPA1.

AB - The transient receptor potential ankyrin 1 (TRPA1) channel, localized to airway sensory nerves, has been proposed to mediate airway inflammation evoked by allergen and cigarette smoke (CS) in rodents, via a neurogenic mechanism. However the limited clinical evidence for the role of neurogenic inflammation in asthma or chronic obstructive pulmonary disease raises an alternative possibility that airway inflammation is promoted by non-neuronal TRPA1.

U2 - 10.1371/journal.pone.0042454

DO - 10.1371/journal.pone.0042454

M3 - Article

C2 - 22905134

VL - 7

SP - e42454

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 8

M1 - e42454

ER -