Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation

Romina Nassini, Pamela Pedretti, Nadia Moretto, Camilla Fusi, Chiara Carnini, Fabrizio Facchinetti, Arturo Roberto Viscomi, Anna Rita Pisano, Susan Stokesberry, Charlott Brunmark, Naila Svitacheva, Lorcan McGarvey, Riccardo Patacchini, Anders B Damholt, Pierangelo Geppetti, Serena Materazzi

Research output: Contribution to journalArticlepeer-review

132 Citations (Scopus)

Abstract

The transient receptor potential ankyrin 1 (TRPA1) channel, localized to airway sensory nerves, has been proposed to mediate airway inflammation evoked by allergen and cigarette smoke (CS) in rodents, via a neurogenic mechanism. However the limited clinical evidence for the role of neurogenic inflammation in asthma or chronic obstructive pulmonary disease raises an alternative possibility that airway inflammation is promoted by non-neuronal TRPA1.
Original languageEnglish
Article numbere42454
Pages (from-to)e42454
JournalPLoS ONE
Volume7
Issue number8
DOIs
Publication statusPublished - 14 Aug 2012

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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