TRARESA: a tissue microarray-based hospital system for biomarker validation and discovery

K. Das, M.F.M. Omar, C.W. Ong, S.B.A. Rashid, B.K. Peh, T.C. Putti, P.H. Tan, K.S. Chia, M. Teh, N. Shah, R. Soong, Manuel Salto-Tellez

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Formalin fixed and paraffin embedded tissue (FFPE) collections in pathology departments are the largest resource for retrospective biomedical research studies. Based on the literature analysis of FFPE related research, as well as our own technical validation, we present the Translational Research Arrays (TRARESA), a tissue microarray centred, hospital based, translational research conceptual framework for both validation and/or discovery of novel biomarkers. TRARESA incorporates the analysis of protein, DNA and RNA in the same samples, correlating with clinical and pathological parameters from each case, and allowing (a) the confirmation of new biomarkers, disease hypotheses and drug targets, and (b) the postulation of novel hypotheses on disease mechanisms and drug targets based on known biomarkers. While presenting TRARESA, we illustrate the use of such a comprehensive approach. The conceptualisation of the role of FFPE-based studies in translational research allows the utilisation of this commodity, and adds to the hypothesis-generating armamentarium of existing high-throughput technologies.
Original languageEnglish
Pages (from-to)441-449
Number of pages9
JournalPathology
Volume40
Issue number5
DOIs
Publication statusPublished - Aug 2008

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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