Trends in candidemia and antifungal susceptibility in a university hospital in Northern Ireland 2001-2006

L. Metwally, M.J. Walker, P.V. Coyle, H.J. O'Neill, C.H. Webb, R. McMullan, R.J. Hay, S. Hedderwick, B.V. McCloskey

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Objectives: To describe the species distribution and antifungal susceptibility trends for documented episodes of candidemia at the Royal Hospitals, Belfast, 2001-2006. Methods: Laboratory-based retrospective observational study of all episodes of candidemia. Results: There were 151 episodes of candidemia. The species recovered were: 96 C. albicans; 26 C. glabrata; 18 C. parapsilosis; five C. tropicalis; four C. guilliermondii; one C. famata and one C. dubliniensis. We separated the data into two periods 2001-2003 and 2004-2006; contrary to the findings of other investigators, there was a notable trends toward increasing frequency of C. albicans and decreasing frequency of non-albicans species over time. Although the proportion of C. albicans, C. parapsilosis and C. tropicalis isolates susceptible to fluconazole was unchanged over time, a trend of decreased susceptibility of C. glabrata to fluconazole was noted over the six-year period. Overall, 73% and 7.7% of C. glabrata isolates had susceptible-dose-dependent and resistant phenotypes, respectively. The percentage of C. glabrata isolates susceptible to fluconazole (MIC
Original languageEnglish
Pages (from-to)174-178
Number of pages5
JournalJournal of infection
Volume55
Issue number2
DOIs
Publication statusPublished - 01 Aug 2007

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology
  • Parasitology
  • Virology
  • Immunology and Allergy
  • Infectious Diseases

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