TY - JOUR
T1 - Trends in candidemia and antifungal susceptibility in a university hospital in Northern Ireland 2001-2006
AU - Metwally, L.
AU - Walker, M.J.
AU - Coyle, P.V.
AU - O'Neill, H.J.
AU - Webb, C.H.
AU - McMullan, R.
AU - Hay, R.J.
AU - Hedderwick, S.
AU - McCloskey, B.V.
N1 - MEDLINE® is the source for the MeSH terms of this document.
PY - 2007/8/1
Y1 - 2007/8/1
N2 - Objectives: To describe the species distribution and antifungal susceptibility trends for documented episodes of candidemia at the Royal Hospitals, Belfast, 2001-2006. Methods: Laboratory-based retrospective observational study of all episodes of candidemia. Results: There were 151 episodes of candidemia. The species recovered were: 96 C. albicans; 26 C. glabrata; 18 C. parapsilosis; five C. tropicalis; four C. guilliermondii; one C. famata and one C. dubliniensis. We separated the data into two periods 2001-2003 and 2004-2006; contrary to the findings of other investigators, there was a notable trends toward increasing frequency of C. albicans and decreasing frequency of non-albicans species over time. Although the proportion of C. albicans, C. parapsilosis and C. tropicalis isolates susceptible to fluconazole was unchanged over time, a trend of decreased susceptibility of C. glabrata to fluconazole was noted over the six-year period. Overall, 73% and 7.7% of C. glabrata isolates had susceptible-dose-dependent and resistant phenotypes, respectively. The percentage of C. glabrata isolates susceptible to fluconazole (MIC
AB - Objectives: To describe the species distribution and antifungal susceptibility trends for documented episodes of candidemia at the Royal Hospitals, Belfast, 2001-2006. Methods: Laboratory-based retrospective observational study of all episodes of candidemia. Results: There were 151 episodes of candidemia. The species recovered were: 96 C. albicans; 26 C. glabrata; 18 C. parapsilosis; five C. tropicalis; four C. guilliermondii; one C. famata and one C. dubliniensis. We separated the data into two periods 2001-2003 and 2004-2006; contrary to the findings of other investigators, there was a notable trends toward increasing frequency of C. albicans and decreasing frequency of non-albicans species over time. Although the proportion of C. albicans, C. parapsilosis and C. tropicalis isolates susceptible to fluconazole was unchanged over time, a trend of decreased susceptibility of C. glabrata to fluconazole was noted over the six-year period. Overall, 73% and 7.7% of C. glabrata isolates had susceptible-dose-dependent and resistant phenotypes, respectively. The percentage of C. glabrata isolates susceptible to fluconazole (MIC
UR - http://www.scopus.com/inward/record.url?partnerID=yv4JPVwI&eid=2-s2.0-34447100229&md5=8c7f69d25b2a226174d4e6b87d43811f
U2 - 10.1016/j.jinf.2007.04.003
DO - 10.1016/j.jinf.2007.04.003
M3 - Article
AN - SCOPUS:34447100229
SN - 0163-4453
VL - 55
SP - 174
EP - 178
JO - Journal of Infection
JF - Journal of Infection
IS - 2
ER -
