Trends in childhood type 1 diabetes incidence in Europe during 1989-2008: evidence of non-uniformity over time in rates of increase

Christopher Patterson, E. Gyurus, Joachim Rosenbauer, Ondrej Cinek, A. Neu, Edith Schober, Roger C Parslow, Geir Joner, Jannet Svensson, C. Castell, Polly J. Bingley, Eugene Schoenle, P. Jarosz-Chobot, Brone Urbonaite, Ulrike Rothe, C. Krzisnik, Constantin Ionescu-Tirgoviste, I. Weets, M. Kocova, Gordana StipancicMira Samardzic, C. De Beaufort, A. Green, G. Dahlquist, G. Soltesz

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The aim of the study was to describe 20-year incidence trends for childhood type 1 diabetes in 23 EURODIAB centres and compare rates of increase in the first (1989-1998) and second (1999-2008) halves of the period.


All registers operate in geographically defined regions and are based on a clinical diagnosis. Completeness of registration is assessed by capture-recapture methodology. Twenty-three centres in 19 countries registered 49,969 new cases of type 1 diabetes in individuals diagnosed before their 15th birthday during the period studied.


Ascertainment exceeded 90% in most registers. During the 20-year period, all but one register showed statistically significant changes in incidence, with rates universally increasing. When estimated separately for the first and second halves of the period, the median rates of increase were similar: 3.4% per annum and 3.3% per annum, respectively. However, rates of increase differed significantly between the first half and the second half for nine of the 21 registers with adequate coverage of both periods; five registers showed significantly higher rates of increase in the first half, and four significantly higher rates in the second half.


The incidence rate of childhood type 1 diabetes continues to rise across Europe by an average of approximately 3-4% per annum, but the increase is not necessarily uniform, showing periods of less rapid and more rapid increase in incidence in some registers. This pattern of change suggests that important risk exposures differ over time in different European countries. Further time trend analysis and comparison of the patterns in defined regions is warranted.
Original languageEnglish
Article numberPMID: 22638547
Pages (from-to)2142-2147
Number of pages6
Issue number8
Publication statusPublished - Aug 2012

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism


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