Trends in incidence of thick, thin and in situ melanoma in Europe.

L. Sacchetto, R. Zanetti, H. Comber, C Bouchardy, DH Brewster, P Broganelli, Maria Dolores Chirlaque Lopez, D. Coza, J. Galceran, Anna Gavin, M Hackl, A Katalinic, S Laronningen, MWJ Louwman, Eileen Morgan, Trude Eid Robsahm, M.J. Sanchez, L. Tryggvadottir, Rosario Tumino, E. Van EyckenS. Vernon, V. Zadnik, S. Rosso

Research output: Contribution to journalArticlepeer-review

48 Citations (Scopus)

Abstract

Background
We analysed trends in incidence for in situ and invasive melanoma in some European countries during the period 1995–2012, stratifying for lesion thickness.

Material and methods
Individual anonymised data from population-based European cancer registries (CRs) were collected and combined in a common database, including information on age, sex, year of diagnosis, histological type, tumour location, behaviour (invasive, in situ) and lesion thickness. Mortality data were retrieved from the publicly available World Health Organization database.

Results
Our database covered a population of over 117 million inhabitants and included about 415,000 skin lesions, recorded by 18 European CRs (7 of them with national coverage). During the 1995–2012 period, we observed a statistically significant increase in incidence for both invasive (average annual percent change (AAPC) 4.0% men; 3.0% women) and in situ (AAPC 7.7% men; 6.2% women) cases.

Discussion
The increase in invasive lesions seemed mainly driven by thin melanomas (AAPC 10% men; 8.3% women). The incidence of thick melanomas also increased, although more slowly in recent years. Correction for lesions of unknown thickness enhanced the differences between thin and thick cases and flattened the trends. Incidence trends varied considerably across registries, but only Netherlands presented a marked increase above the boundaries of a funnel plot that weighted estimates by their precision. Mortality from invasive melanoma has continued to increase in Norway, Iceland (but only for elder people), the Netherlands and Slovenia.
Original languageEnglish
Pages (from-to)108-118
JournalEuropean Journal of Cancer
Volume92
Early online date31 Jan 2018
DOIs
Publication statusPublished - 01 Apr 2018

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