Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands.

F. Cuenca; O. Greciano; M. Gunaratnam; Shozeb Haider; D. Munnur; R. Nanjunda; W.D. Wilson; S. Neidle

doi:10.1016/j.bmcl.2008.01.050

Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands.

F. Cuenca, O. Greciano, M. Gunaratnam, Shozeb Haider, D. Munnur, R. Nanjunda, W.D. Wilson, S. Neidle

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

129 Citations (Scopus)

Abstract

A series of tri- and tetra-substituted naphthalene diimides have been designed and synthesized. Several compounds show exceptional affinity for telomeric G-quadruplex DNA in classical and competition FRET assays and SPR studies. They inhibit telomerase in the TRAP assay, and show potent senescence-based short-term anti-proliferative effects on MCF7 and A549 cancer cell lines, and localize in the nucleus and particularly the nucleolus of MCF7 cells.

Original language	English
Pages (from-to)	1668-1673
Number of pages	6
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	18(5)
Issue number	5
DOIs	https://doi.org/10.1016/j.bmcl.2008.01.050
Publication status	Published - 01 Mar 2008

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Organic Chemistry
Drug Discovery
Pharmaceutical Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bmcl.2008.01.050

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title = "Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands.",

abstract = "A series of tri- and tetra-substituted naphthalene diimides have been designed and synthesized. Several compounds show exceptional affinity for telomeric G-quadruplex DNA in classical and competition FRET assays and SPR studies. They inhibit telomerase in the TRAP assay, and show potent senescence-based short-term anti-proliferative effects on MCF7 and A549 cancer cell lines, and localize in the nucleus and particularly the nucleolus of MCF7 cells.",

author = "F. Cuenca and O. Greciano and M. Gunaratnam and Shozeb Haider and D. Munnur and R. Nanjunda and W.D. Wilson and S. Neidle",

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T1 - Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands.

AU - Cuenca, F.

AU - Greciano, O.

AU - Gunaratnam, M.

AU - Haider, Shozeb

AU - Munnur, D.

AU - Nanjunda, R.

AU - Wilson, W.D.

AU - Neidle, S.

PY - 2008/3/1

Y1 - 2008/3/1

N2 - A series of tri- and tetra-substituted naphthalene diimides have been designed and synthesized. Several compounds show exceptional affinity for telomeric G-quadruplex DNA in classical and competition FRET assays and SPR studies. They inhibit telomerase in the TRAP assay, and show potent senescence-based short-term anti-proliferative effects on MCF7 and A549 cancer cell lines, and localize in the nucleus and particularly the nucleolus of MCF7 cells.

AB - A series of tri- and tetra-substituted naphthalene diimides have been designed and synthesized. Several compounds show exceptional affinity for telomeric G-quadruplex DNA in classical and competition FRET assays and SPR studies. They inhibit telomerase in the TRAP assay, and show potent senescence-based short-term anti-proliferative effects on MCF7 and A549 cancer cell lines, and localize in the nucleus and particularly the nucleolus of MCF7 cells.

U2 - 10.1016/j.bmcl.2008.01.050

DO - 10.1016/j.bmcl.2008.01.050

M3 - Article

C2 - 18243701

SN - 1464-3405

VL - 18(5)

SP - 1668

EP - 1673

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

IS - 5

ER -

Tri- and tetra-substituted naphthalene diimides as potent G-quadruplex ligands.

Abstract

ASJC Scopus subject areas

UN SDGs

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