Tridecaptin-Inspired Antimicrobial Peptides with Activity Against Multidrug-Resistant Gram-Negative Bacteria

Ross Ballantine, Conor E. McCallion, Elie Nassour, Sima Tokajian , Stephen Cochrane

Research output: Contribution to journalArticle

5 Citations (Scopus)
165 Downloads (Pure)

Abstract

Antimicrobial peptides are a rich source of potential antibiotic candidates. The tridecaptins, a family of linear lipo-tridecapeptides, are easily synthesized and show strong activity against Gram-negative bacteria. However, their composition includes several expensive amino acids, such as D/L diaminobutyric acid and Dallo-isoleucine, significantly increasing their cost of synthesis. Herein, we report a series of new tridecaptin derivatives that are much cheaper to synthesize and retain strong activity against multidrug-resistant Gram-negative bacteria.
Original languageEnglish
Pages (from-to)484-487
Number of pages4
JournalMed Chem Commun
Volume10
Issue number3
DOIs
Publication statusPublished - 12 Mar 2019

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