Tridecaptin-Inspired Antimicrobial Peptides with Activity Against Multidrug-Resistant Gram-Negative Bacteria

Ross Ballantine; Conor E.  McCallion; Elie  Nassour; Sima  Tokajian; Stephen Cochrane

doi:10.1039/C9MD00031C

Tridecaptin-Inspired Antimicrobial Peptides with Activity Against Multidrug-Resistant Gram-Negative Bacteria

Ross Ballantine, Conor E. McCallion, Elie Nassour, Sima Tokajian , Stephen Cochrane

School of Chemistry and Chemical Engineering

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

251 Downloads (Pure)

Abstract

Antimicrobial peptides are a rich source of potential antibiotic candidates. The tridecaptins, a family of linear lipo-tridecapeptides, are easily synthesized and show strong activity against Gram-negative bacteria. However, their composition includes several expensive amino acids, such as D/L diaminobutyric acid and Dallo-isoleucine, significantly increasing their cost of synthesis. Herein, we report a series of new tridecaptin derivatives that are much cheaper to synthesize and retain strong activity against multidrug-resistant Gram-negative bacteria.

Original language	English
Pages (from-to)	484-487
Number of pages	4
Journal	Med Chem Commun
Volume	10
Issue number	3
DOIs	https://doi.org/10.1039/C9MD00031C
Publication status	Published - 12 Mar 2019

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10.1039/C9MD00031CLicence: CC BY

Tridecaptin-inspired antimicrobial peptides with activity against multidrug-resistant Gram-negative bacteria
Copyright 2019 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 1.54 MBLicence: CC BY

Structural and mechanistic studies on antimicrobial peptides that target multi-drug resistant bacteria
Ballantine, R. (Author), Cochrane, S. (Supervisor) & Stevenson, P. (Supervisor), Jul 2021
Student thesis: Doctoral Thesis › Doctor of Philosophy

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Tridecaptin-Inspired Antimicrobial Peptides with Activity Against Multidrug-Resistant Gram-Negative Bacteria

Abstract

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Student theses

Structural and mechanistic studies on antimicrobial peptides that target multi-drug resistant bacteria

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