Antimicrobial peptides are a rich source of potential antibiotic candidates. The tridecaptins, a family of linear lipo-tridecapeptides, are easily synthesized and show strong activity against Gram-negative bacteria. However, their composition includes several expensive amino acids, such as D/L diaminobutyric acid and Dallo-isoleucine, significantly increasing their cost of synthesis. Herein, we report a series of new tridecaptin derivatives that are much cheaper to synthesize and retain strong activity against multidrug-resistant Gram-negative bacteria.
Ballantine, R., McCallion, C. E., Nassour, E., Tokajian , S., & Cochrane, S. (2019). Tridecaptin-Inspired Antimicrobial Peptides with Activity Against Multidrug-Resistant Gram-Negative Bacteria. Med Chem Commun, 10(3), 484-487. https://doi.org/10.1039/C9MD00031C