Triggered drug delivery from biomaterials

Colin McCoy, C. Brady, J.F. Cowley, S.M. McGlinchey, N. McGoldrick, D.J. Kinnear, Gavin Andrews, David Jones

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Importance of the field: Conventional dosing methods are frequently unable to deliver the clinical requirement of the patient. The ability to control the delivery of drugs from implanted materials is difficult to achieve, but offers promise in diverse areas such as infection-resistant medical devices and 10 responsive implants for diabetics. Areas covered in this review: This review gives a broad overview of recent progress in the use of triggers that can be used to achieve modulation of drug release rates from implantable biomaterials. In particular, these can be classified as being responsive to one or more of the following stimuli: a 15 chemical species, light, heat, magnetism, ultrasound and mechanical force. What the reader will gain: An overview of the potential for triggered drug delivery to give methods for tailoring the dose, location and time of release of a wide range of drugs where traditional dosing methods are not suitable. Particular emphasis is given to recently reported systems, and important 20 historical reports are included. Take home message: The use of externally or internally applied triggers of drug delivery to biomaterials has significant potential for improved delivery modalities and infection resistance.
Original languageEnglish
Pages (from-to)605-616
Number of pages12
JournalExpert Opinion on Drug Delivery
Volume7
Issue number5
DOIs
Publication statusPublished - 2010

ASJC Scopus subject areas

  • Pharmaceutical Science

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    McCoy, C., Brady, C., Cowley, J. F., McGlinchey, S. M., McGoldrick, N., Kinnear, D. J., Andrews, G., & Jones, D. (2010). Triggered drug delivery from biomaterials. Expert Opinion on Drug Delivery, 7(5), 605-616. https://doi.org/10.1517/17425241003677731