TRIM proteins in blood cancers

Lisa J. Crawford, Cliona K. Johnston, Alexandra E. Irvine*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)
302 Downloads (Pure)


Post-translational modification of proteins with ubiquitin plays a central role in regulating numerous cellular processes. E3 ligases determine the specificity of ubiquitination by mediating the transfer of ubiquitin to substrate proteins. The family of tripartite motif (TRIM) proteins make up one of the largest subfamilies of E3 ligases. Accumulating evidence suggests that dysregulation of TRIM proteins is associated with a variety of diseases. In this review we focus on the involvement of TRIM proteins in blood cancers.

Original languageEnglish
Pages (from-to)1-9
JournalJournal of Cell Communication and Signaling
Early online date06 Nov 2017
Publication statusEarly online date - 06 Nov 2017


  • E3 ligase
  • Leukaemia
  • Lymphoma
  • Multiple myeloma
  • TRIM proteins
  • Ubiquitin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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