Abstract
Post-translational modification of proteins with ubiquitin plays a central role in regulating numerous cellular processes. E3 ligases determine the specificity of ubiquitination by mediating the transfer of ubiquitin to substrate proteins. The family of tripartite motif (TRIM) proteins make up one of the largest subfamilies of E3 ligases. Accumulating evidence suggests that dysregulation of TRIM proteins is associated with a variety of diseases. In this review we focus on the involvement of TRIM proteins in blood cancers.
| Original language | English |
|---|---|
| Pages (from-to) | 1-9 |
| Journal | Journal of Cell Communication and Signaling |
| Early online date | 06 Nov 2017 |
| DOIs | |
| Publication status | Early online date - 06 Nov 2017 |
Keywords
- E3 ligase
- Leukaemia
- Lymphoma
- Multiple myeloma
- TRIM proteins
- Ubiquitin
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology
Access to Document
- TRIM proteins in blood cancers
Copyright 2017the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.