Triple-Modal Imaging of Magnetically-Targeted Nanocapsules in Solid Tumours In Vivo

Jie Bai, Julie T-W Wang, Noelia Rubio, Andrea Protti, Hamed Heidari, Riham Elgogary, Paul Southern, Wafa' T Al-Jamal, Jane K Sosabowski, Ajay M Shah, Sara Bals, Quentin A Pankhurst, Khuloud T Al-Jamal

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)
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Triple-modal imaging magnetic nanocapsules, encapsulating hydrophobic superparamagnetic iron oxide nanoparticles, are formulated and used to magnetically target solid tumours after intravenous administration in tumour-bearing mice. The engineered magnetic polymeric nanocapsules m-NCs are ~200 nm in size with negative Zeta potential and shown to be spherical in shape. The loading efficiency of superparamagnetic iron oxide nanoparticles in the m-NC was ~100%. Up to ~3- and ~2.2-fold increase in tumour uptake at 1 and 24 h was achieved, when a static magnetic field was applied to the tumour for 1 hour. m-NCs, with multiple imaging probes (e.g. indocyanine green, superparamagnetic iron oxide nanoparticles and indium-111), were capable of triple-modal imaging (fluorescence/magnetic resonance/nuclear imaging) in vivo. Using triple-modal imaging is to overcome the intrinsic limitations of single modality imaging and provides complementary information on the spatial distribution of the nanocarrier within the tumour. The significant findings of this study could open up new research perspectives in using novel magnetically-responsive nanomaterials in magnetic-drug targeting combined with multi-modal imaging.

Original languageEnglish
Pages (from-to)342-56
Issue number3
Publication statusPublished - 01 Jan 2016
Externally publishedYes


  • Administration, Intravenous
  • Animals
  • Disease Models, Animal
  • Female
  • Ferric Compounds
  • Magnetics
  • Mice, Inbred BALB C
  • Multimodal Imaging
  • Nanocapsules
  • Neoplasms
  • Journal Article
  • Research Support, Non-U.S. Gov't

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