Triterpenoids from Pulsatilla chinensis

WC Ye*, NN Ji, SX Zhao, JH Liu, T Ye, MA McKervey, P Stevenson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

100 Citations (Scopus)

Abstract

A new lupane type triterpenic acid, pulsatillic acid, and two new lupane type triterpenoid glycosides, pulsatilloside A and B, along with the known 23-hydroxybetulinic acid were isolated from the roots of Pulsatilla chinensis. Their structures were characterized as 3-oxo-23-hydroxy-lup-20(29)-en-28-oic acid, 3 beta, 23-dihydroxy-lup-20(29)-en-28-oic acid 3-O-alpha-L-arabinopyranoside and 3 beta, 23-dihydroxy-lup-20(29)-en-28-oic acid 28-O-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranoside on the basis of hydrolysis and spectral evidence including two-dimensional relay HOHAHA, one-dimensional multiple relay COSY and ROESY NMR techniques. Pulsatillic acid exhibited cytotoxic activities against P-388, Lewis lung carcinoma and human large-cell lung carcinoma.

Original languageEnglish
Pages (from-to)799-802
Number of pages4
JournalPhytochemistry
Volume42
Issue number3
Publication statusPublished - Jun 1996

Keywords

  • Pulsatilla chinensis
  • ranunculaceae
  • triterpenic acid
  • triterpenoid glycosides
  • 23-hydroxybetulinic acid
  • pulsatillic acid
  • pulsatilloside A and B

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