TRP channels in vascular disorders

Alexander V Zholos, Timothy M Curtis

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

In recent years, research on the roles of TRP channels in vascular function and disease has undergone a rapid expansion from tens of reports published in the early 2000s to several hundreds of papers published to date. Multiple TRP subtypes are expressed in vascular smooth muscle cells and endothelial cells, where they form diverse non-selective cation channels permeable to Ca2+. These channels mediate Ca2+ entry following receptor stimulation, Ca2+ store depletion and mechanical stimulation of vascular myocytes and endothelial cells. The complex molecular composition and signalling pathways leading to the activation of various vascular TRP channels and the growing evidence for their involvement in various vascular disorders, including dysregulation of vascular tone and hypertension, impaired endothelium-dependent vasodilatation, increased endothelial permeability, occlusive vascular disease, vascular injury and oxidative stress, are summarised and discussed in this review.
Original languageEnglish
Pages (from-to)295-309
JournalCurrent Topics In Medicinal Chemistry
Volume13
Issue number3
DOIs
Publication statusPublished - 2013

ASJC Scopus subject areas

  • Drug Discovery

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