Tuning the Antimicrobial Activity of Low Molecular Weight Hydrogels Using Dopamine Autoxidation

Emily R. Cross; Sophie Coulter; Ana Fuentes-Capparrós; Kate  McAulay; Ralf Schweins; Garry Laverty; Dave Adams

doi:DOI: 10.1039/d0cc02569k

Tuning the Antimicrobial Activity of Low Molecular Weight Hydrogels Using Dopamine Autoxidation

Emily R. Cross, Sophie Coulter, Ana Fuentes-Capparrós, Kate McAulay, Ralf Schweins, Garry Laverty^*, Dave Adams^*

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

80 Downloads (Pure)

Abstract

We present a method to trigger the formation of dipeptide-basedhydrogels by the simple addition of dopamine. Dopamineundergoes oxidation in air, reducing the pH to induce gelation. Theproduction of polydopamine and release of reactive oxygen speciessuch as hydrogen peroxide confers antimicrobial activity. Gelstiffness can be controlled by modulating the initial starting pH ofthe gelator solution. We can use this method to tune theantimicrobial activity of the gels, with gels that are less stiffdemonstrating increased bactericidal efficacy against Grampositive bacteria.

Original language	English
Pages (from-to)	8135-8138
Number of pages	4
Journal	Chemical Communications
Volume	56
Early online date	10 Jun 2020
DOIs	https://doi.org/DOI: 10.1039/d0cc02569k
Publication status	Early online date - 10 Jun 2020

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DOI: 10.1039/d0cc02569kLicence: CC BY

Tuning the Antimicrobial Activity of Low Molecular Weight Hydrogels Using Dopamine Autoxidation
© 2020 The Authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 1.09 MBLicence: CC BY

Peptide-mimetic hydrogels as a long-acting drug delivery platform for HIV/AIDS
Coulter, S. (Author), Laverty, G. (Supervisor) & Malcolm, K. (Supervisor), Jul 2020
Student thesis: Doctoral Thesis › Doctor of Philosophy

Cite this

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title = "Tuning the Antimicrobial Activity of Low Molecular Weight Hydrogels Using Dopamine Autoxidation",

abstract = "We present a method to trigger the formation of dipeptide-basedhydrogels by the simple addition of dopamine. Dopamineundergoes oxidation in air, reducing the pH to induce gelation. Theproduction of polydopamine and release of reactive oxygen speciessuch as hydrogen peroxide confers antimicrobial activity. Gelstiffness can be controlled by modulating the initial starting pH ofthe gelator solution. We can use this method to tune theantimicrobial activity of the gels, with gels that are less stiffdemonstrating increased bactericidal efficacy against Grampositive bacteria.",

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AU - Cross, Emily R.

AU - Coulter, Sophie

AU - Fuentes-Capparrós, Ana

AU - McAulay, Kate

AU - Schweins, Ralf

AU - Laverty, Garry

AU - Adams, Dave

PY - 2020/6/10

Y1 - 2020/6/10

N2 - We present a method to trigger the formation of dipeptide-basedhydrogels by the simple addition of dopamine. Dopamineundergoes oxidation in air, reducing the pH to induce gelation. Theproduction of polydopamine and release of reactive oxygen speciessuch as hydrogen peroxide confers antimicrobial activity. Gelstiffness can be controlled by modulating the initial starting pH ofthe gelator solution. We can use this method to tune theantimicrobial activity of the gels, with gels that are less stiffdemonstrating increased bactericidal efficacy against Grampositive bacteria.

AB - We present a method to trigger the formation of dipeptide-basedhydrogels by the simple addition of dopamine. Dopamineundergoes oxidation in air, reducing the pH to induce gelation. Theproduction of polydopamine and release of reactive oxygen speciessuch as hydrogen peroxide confers antimicrobial activity. Gelstiffness can be controlled by modulating the initial starting pH ofthe gelator solution. We can use this method to tune theantimicrobial activity of the gels, with gels that are less stiffdemonstrating increased bactericidal efficacy against Grampositive bacteria.

U2 - DOI: 10.1039/d0cc02569k

DO - DOI: 10.1039/d0cc02569k

M3 - Article

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VL - 56

SP - 8135

EP - 8138

JO - Chemical Communications

JF - Chemical Communications

ER -

Tuning the Antimicrobial Activity of Low Molecular Weight Hydrogels Using Dopamine Autoxidation

Abstract

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Student theses

Peptide-mimetic hydrogels as a long-acting drug delivery platform for HIV/AIDS

Cite this