We present a method to trigger the formation of dipeptide-basedhydrogels by the simple addition of dopamine. Dopamineundergoes oxidation in air, reducing the pH to induce gelation. Theproduction of polydopamine and release of reactive oxygen speciessuch as hydrogen peroxide confers antimicrobial activity. Gelstiffness can be controlled by modulating the initial starting pH ofthe gelator solution. We can use this method to tune theantimicrobial activity of the gels, with gels that are less stiffdemonstrating increased bactericidal efficacy against Grampositive bacteria.
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Coulter, S., Jul 2020
Student thesis: Doctoral Thesis › Doctor of Philosophy