Tuning the Antimicrobial Activity of Low Molecular Weight Hydrogels Using Dopamine Autoxidation

Emily R. Cross, Sophie Coulter, Ana Fuentes-Capparrós, Kate McAulay, Ralf Schweins, Garry Laverty*, Dave Adams*

*Corresponding author for this work

Research output: Contribution to journalArticle

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Abstract

We present a method to trigger the formation of dipeptide-basedhydrogels by the simple addition of dopamine. Dopamineundergoes oxidation in air, reducing the pH to induce gelation. Theproduction of polydopamine and release of reactive oxygen speciessuch as hydrogen peroxide confers antimicrobial activity. Gelstiffness can be controlled by modulating the initial starting pH ofthe gelator solution. We can use this method to tune theantimicrobial activity of the gels, with gels that are less stiffdemonstrating increased bactericidal efficacy against Grampositive bacteria.
Original languageEnglish
Pages (from-to)8135-8138
Number of pages4
JournalChemical Communications
Volume56
Early online date10 Jun 2020
DOIs
Publication statusEarly online date - 10 Jun 2020

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  • Student Theses

    Peptide-mimetic hydrogels as a long-acting drug delivery platform for HIV/AIDS

    Author: Coulter, S., Jul 2020

    Supervisor: Laverty, G. (Supervisor) & Malcolm, K. (Supervisor)

    Student thesis: Doctoral ThesisDoctor of Philosophy

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