Type XVIII collagen degradation products in acute lung injury

G.D. Perkins, N. Nathani, A.G. Richter, D. Park, M. Shyamsundar, R. Heljasvaara, T. Pihlajaniemi, M. Manji, W. Tunnicliffe, Danny McAuley, F. Gao, D.R. Thickett

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Introduction In acute lung injury, repair of the damaged alveolar-capillary barrier is an essential part of recovery. Endostatin is a 20 to 28 kDa proteolytic fragment of the basement membrane collagen XVIII, which has been shown to inhibit angiogenesis via action on endothelial cells. We hypothesised that endostatin may have a role in inhibiting lung repair in patients with lung injury. The aims of the study were to determine if endostatin is elevated in the plasma/bronchoalveolar lavage fluid of patients with acute lung injury and ascertain whether the levels reflect the severity of injury and alveolar inflammation, and to assess if endostatin changes occur early after the injurious lung stimuli of one lung ventilation and lipopolysaccharide (LPS) challenge.
Original languageEnglish
Article numberR52
Pages (from-to)000-000
Number of pages1
JournalCritical Care
Issue number2
Publication statusPublished - 09 Apr 2009

ASJC Scopus subject areas

  • Medicine(all)
  • Critical Care and Intensive Care Medicine

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    Perkins, G. D., Nathani, N., Richter, A. G., Park, D., Shyamsundar, M., Heljasvaara, R., Pihlajaniemi, T., Manji, M., Tunnicliffe, W., McAuley, D., Gao, F., & Thickett, D. R. (2009). Type XVIII collagen degradation products in acute lung injury. Critical Care, 13(2), 000-000. [R52]. https://doi.org/10.1186/cc7779