Ubiquitin‐dependent regulation of MYC: a promising therapeutic target

Bryony G. Kennedy; Jonathan J. Morgan; Lisa J. Crawford

doi:10.1002/ctd2.190

Ubiquitin‐dependent regulation of MYC: a promising therapeutic target

Bryony G. Kennedy
, Jonathan J. Morgan
, Lisa J. Crawford^*

^*Corresponding author for this work

Research output: Contribution to journal › Comment/debate › peer-review

108 Downloads (Pure)

Abstract

Commentary on: Xiong Y, Wang L, Xu S, Fu B, Che Y, Zaky MY, Tian R, Yao R, Guo D, Sha Z, Lin F, Lin X, Wu H. Small molecule Z363 co-regulates TAF10 and MYC via the E3 ligase TRIP12 to suppress tumour growth. Clin Transl Med. 2023;13(1):e1153. doi: 10.1002/ctm2.1153

Original language	English
Article number	e190
Journal	Clinical and Translational Discovery
Volume	3
Issue number	2
DOIs	https://doi.org/10.1002/ctd2.190
Publication status	Published - 01 Apr 2023

Keywords

COMMENTARY
E3 ligase
MYC
TRIP12
ubiqutin

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10.1002/ctd2.190Licence: CC BY

Ubiquitin‐dependent regulation of MYC: a promising therapeutic target
Copyright 2023 The Authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 331 KBLicence: CC BY

The development and evaluation of small molecule inhibitors of HUWE1 for the treatment of multiple myeloma
Kennedy, B. (Author), Williams, R. (Supervisor) & Crawford, L. (Supervisor), Jul 2024
Student thesis: Doctoral Thesis › Doctor of Philosophy

Cite this

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title = "Ubiquitin‐dependent regulation of MYC: a promising therapeutic target",

abstract = "Commentary on: Xiong Y, Wang L, Xu S, Fu B, Che Y, Zaky MY, Tian R, Yao R, Guo D, Sha Z, Lin F, Lin X, Wu H. Small molecule Z363 co-regulates TAF10 and MYC via the E3 ligase TRIP12 to suppress tumour growth. Clin Transl Med. 2023;13(1):e1153. doi: 10.1002/ctm2.1153 ",

keywords = "COMMENTARY, E3 ligase, MYC, TRIP12, ubiqutin",

author = "Kennedy, \{Bryony G.\} and Morgan, \{Jonathan J.\} and Crawford, \{Lisa J.\}",

year = "2023",

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day = "1",

doi = "10.1002/ctd2.190",

language = "English",

volume = "3",

journal = "Clinical and Translational Discovery",

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T1 - Ubiquitin‐dependent regulation of MYC: a promising therapeutic target

AU - Kennedy, Bryony G.

AU - Morgan, Jonathan J.

AU - Crawford, Lisa J.

PY - 2023/4/1

Y1 - 2023/4/1

N2 - Commentary on: Xiong Y, Wang L, Xu S, Fu B, Che Y, Zaky MY, Tian R, Yao R, Guo D, Sha Z, Lin F, Lin X, Wu H. Small molecule Z363 co-regulates TAF10 and MYC via the E3 ligase TRIP12 to suppress tumour growth. Clin Transl Med. 2023;13(1):e1153. doi: 10.1002/ctm2.1153

AB - Commentary on: Xiong Y, Wang L, Xu S, Fu B, Che Y, Zaky MY, Tian R, Yao R, Guo D, Sha Z, Lin F, Lin X, Wu H. Small molecule Z363 co-regulates TAF10 and MYC via the E3 ligase TRIP12 to suppress tumour growth. Clin Transl Med. 2023;13(1):e1153. doi: 10.1002/ctm2.1153

KW - COMMENTARY

KW - E3 ligase

KW - MYC

KW - TRIP12

KW - ubiqutin

U2 - 10.1002/ctd2.190

DO - 10.1002/ctd2.190

M3 - Comment/debate

SN - 2768-0622

VL - 3

JO - Clinical and Translational Discovery

JF - Clinical and Translational Discovery

IS - 2

M1 - e190

ER -

Ubiquitin‐dependent regulation of MYC: a promising therapeutic target

Abstract

Keywords

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Student theses

The development and evaluation of small molecule inhibitors of HUWE1 for the treatment of multiple myeloma

Cite this