Ultraviolet irradiation for the prevention of graft-versus-host disease and graft rejection in bone marrow transplantation

J G Hudson, M Lawler, D H Pamphilon, Mark Lawler

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10 Citations (Scopus)

Abstract

This review describes an approach to the prevention of graft-versus-host disease (GVHD) and graft rejection following allogeneic BMT that differs from conventional methods. Ultraviolet (UV) irradiation inhibits the proliferative responses of lymphoid cells to mitogens and alloantigens by inactivation of T lymphocytes and dendritic cells, and in animal models this can prevent both GVHD and graft rejection. It is important that the marrow repopulating capacity of haemopoietic stem cells is not damaged by the irradiation process. We have found that polymorphic microsatellite markers are a sensitive way of assessing the impact of UV irradiation on chimerism after BMT in rodents.

Original languageEnglish
Pages (from-to)511-6
Number of pages6
JournalBone Marrow Transplantation
Volume14
Issue number4
Publication statusPublished - Oct 1994

Keywords

  • Antigen-Presenting Cells
  • Bone Marrow Transplantation
  • Graft Rejection
  • Graft vs Host Disease
  • Humans
  • Radiation Chimera
  • T-Lymphocytes
  • Ultraviolet Therapy

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