Under the right conditions: protecting podocytes from diabetes-induced damage

Imran HA Ali, Derek P. Brazil

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)
171 Downloads (Pure)

Abstract

Hyperglycemia-induced damage to the glomerular podocyte is thought to be a critical early event in diabetic nephropathy. Interventions that prevent podocyte damage or loss have been shown to have potential for the treatment of diabetic nephropathy. New data show that conditioned medium from adipocyte-derived mesenchymal stem cells has the potential to protect podocytes from high-glucose-induced damage. Furthermore, epidermal growth factor may be the critical ingredient mediating this effect. These data suggest that components of the conditioned medium of mesenchymal stem cells, in addition to the cells themselves, may have potential for the treatment of diseases such as diabetic nephropathy.
Original languageEnglish
Article number119
Number of pages2
JournalStem Cell Research & Therapy
Volume4
Issue number5
DOIs
Publication statusPublished - 02 Oct 2013

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Molecular Medicine
  • Cell Biology
  • Medicine (miscellaneous)

Fingerprint

Dive into the research topics of 'Under the right conditions: protecting podocytes from diabetes-induced damage'. Together they form a unique fingerprint.

Cite this